Antibiotic-derived radiotracers for positron emission tomography : nuclear or “unclear” infection imaging?
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Date
Authors
Gouws, Arno Christiaan
Kruger, Hendrik Gerhardus
Gheysens, Olivier
Zeevaart, Jan Rijn
Govender, Thavendran
Naicker, Tricia
Ebenhan, Thomas
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body
imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET)
scanners are encouraging prospects to investigate new concepts, which could transform clinical care of complex infectious
diseases. Researchers are aiming towards the extension beyond the routinely available radiopharmaceuticals and are
looking for more effective tools that interact directly with causative pathogens. We reviewed and critically evaluated
(challenges or pitfalls) antibiotic-derived PET radiopharmaceutical development efforts aimed at infection imaging. We
considered both radiotracer development for infection imaging and radio-antibiotic PET imaging supplementing other
tools for pharmacologic drug characterization; overall, a total of 20 original PET radiotracers derived from eleven
approved antibiotics.
Description
Keywords
Antibiotic-derived PET, Imaging of infection, Radiolabeling, Radiotracers, Positron emission tomography (PET)
Sustainable Development Goals
Citation
Gouws, A.C., Kruger, H.G., Gheysens, O. et al. 2022, 'Antibiotic-derived radiotracers for positron emission tomography : nuclear or “unclear” infection imaging?', Angewandte Chemie International Edition, vol. 61, art. e202204955, doi : 10.1002/anie.202204955.