Antibiotic-derived radiotracers for positron emission tomography : nuclear or “unclear” infection imaging?

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Authors

Gouws, Arno Christiaan
Kruger, Hendrik Gerhardus
Gheysens, Olivier
Zeevaart, Jan Rijn
Govender, Thavendran
Naicker, Tricia
Ebenhan, Thomas

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Abstract

The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are encouraging prospects to investigate new concepts, which could transform clinical care of complex infectious diseases. Researchers are aiming towards the extension beyond the routinely available radiopharmaceuticals and are looking for more effective tools that interact directly with causative pathogens. We reviewed and critically evaluated (challenges or pitfalls) antibiotic-derived PET radiopharmaceutical development efforts aimed at infection imaging. We considered both radiotracer development for infection imaging and radio-antibiotic PET imaging supplementing other tools for pharmacologic drug characterization; overall, a total of 20 original PET radiotracers derived from eleven approved antibiotics.

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Keywords

Antibiotic-derived PET, Imaging of infection, Radiolabeling, Radiotracers, Positron emission tomography (PET)

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Citation

Gouws, A.C., Kruger, H.G., Gheysens, O. et al. 2022, 'Antibiotic-derived radiotracers for positron emission tomography : nuclear or “unclear” infection imaging?', Angewandte Chemie International Edition, vol. 61, art. e202204955, doi : 10.1002/anie.202204955.