Effect of smoking on acute phase reactants, stress hormone responses and vitamin C in pulmonary tuberculosis

dc.contributor.authorOpolot, John O.
dc.contributor.authorTheron, Annette J.
dc.contributor.authorMacPhail, Patrick
dc.contributor.authorFeldman, Charles
dc.contributor.authorAnderson, Ronald
dc.date.accessioned2017-08-29T10:01:42Z
dc.date.available2017-08-29T10:01:42Z
dc.date.issued2017-06
dc.description.abstractBACKGROUND : Chronic inflammation, possibly exacerbated by cigarette smoking, is considered to be the primary cause of pulmonary damage in patients with tuberculosis (TB). However, the mechanisms which underpin these harmful inflammatory responses, have not been well documented. OBJECTIVES : The current study was undertaken to determine possible associations between systemic biomarkers of inflammation (acute phase reactants, stress hormones, leukocyte vitamin C) and smoking status in patients (n=71, 20 smokers) with newly-diagnosed pulmonary TB presenting at a tertiary hospital, Johannesburg, South Africa. METHODS : Plasma concentrations of C-reactive protein (CRP), ferritin, cortisol, epinephrine, norepinephrine, dopamine and leukocyte vitamin C were measured using a combination of immunonephelometric, radioimmunoassay, immunochromatographic and spectrophotometric procedures. Demographic, clinical and laboratory data was captured and analysed by parametric and non-parametric analyses where appropriate. RESULTS : Smokers were predominantly males (P<0.0001), of older age (P<0.0003) with a significantly lower body mass index (P<0.03). Plasma levels of CRP, ferritin and dopamine were higher in the group of smokers in the setting of lower levels of epinephrine, and leukocyte vitamin C, with CRP and vitamin C attaining statistical significance (P<0.04 and P<0.02 respectively). Those of cortisol and norepinephrine were comparable to those of non-smokers, as were radiographic changes and clinical indices of disease activity. CONCLUSION : Cigarette smoking is associated with an exaggerated systemic inflammatory response in pulmonary TB in the setting of decreased concentrations of leukocyte vitamin C. Although no significant associations with radiographic changes and most clinical indices of disease activity were evident on presentation, these pro-inflammatory interactions may have prognostic significance.en_ZA
dc.description.departmentImmunologyen_ZA
dc.description.librarianam2017en_ZA
dc.description.sponsorshipCharles Feldman is supported by the National Research Foundation (SA).en_ZA
dc.description.urihttp://www.bioline.org.br/hsen_ZA
dc.identifier.citationOpolot, J.O., Theron, A.J., MacPhail, P., Feldman, C. & Anderson, R. Effect of smoking on acute phase reactants, stress hormone responses and vitamin C in pulmonary tuberculosis. Afri Health Sci. 2017;17(2): 337-345. https://dx.DOI.org/ 10.4314/ahs.v17i2.7.en_ZA
dc.identifier.issn1680-6905 (print)
dc.identifier.issn1729-0503 (online)
dc.identifier.other10.4314/ahs.v17i2.7
dc.identifier.urihttp://hdl.handle.net/2263/62138
dc.language.isoenen_ZA
dc.publisherMakerere University Medical Schoolen_ZA
dc.rightsMakerere University Medical Schoolen_ZA
dc.subjectCatecholaminesen_ZA
dc.subjectC-Reactive proteinen_ZA
dc.subjectFerritinen_ZA
dc.subjectLeukocyte vitamin C.en_ZA
dc.subjectCultureen_ZA
dc.subjectDepletionen_ZA
dc.subjectInfectionen_ZA
dc.subjectIncreasesen_ZA
dc.subjectConversionen_ZA
dc.subjectTuberculosis (TB)en_ZA
dc.subjectMycobacterium tuberculosis (MTB)en_ZA
dc.subjectRisken_ZA
dc.subjectJohannesburg, South Africaen_ZA
dc.titleEffect of smoking on acute phase reactants, stress hormone responses and vitamin C in pulmonary tuberculosisen_ZA
dc.typeArticleen_ZA

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