Antimitotic drugs in the treatment of cancer
| dc.contributor.author | Janse van Vuuren, Rustelle | |
| dc.contributor.author | Visagie, M.H. (Michelle Helen) | |
| dc.contributor.author | Theron, Anne Elisabeth | |
| dc.contributor.author | Joubert, Annie M. | |
| dc.contributor.email | michelle.visagie@up.ac.za | en_ZA |
| dc.date.accessioned | 2015-12-11T06:34:54Z | |
| dc.date.available | 2015-12-11T06:34:54Z | |
| dc.date.issued | 2015-12 | |
| dc.description.abstract | Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that are highly validated chemotherapy agents. However, antimitotic drug cytotoxicity to non-tumorigenic cells and multiple cancer resistance developed in response to drugs such as taxanes and vinca alkaloids are obstacles faced in both the clinical and basic research field to date. In this review, the classes of antimitotic compounds, their mechanisms of action and cancer cell resistance to chemotherapy and other limitations of current antimitotic compounds are highlighted, as well as the potential of novel 17-β estradiol analogs as cancer treatment. | en_ZA |
| dc.description.librarian | hb2015 | en_ZA |
| dc.description.sponsorship | Medical Research Council of South Africa, the Research Committee of the Faculty of Health Sciences of the University of Pretoria, the Cancer association of South Africa and the National Research Foundation. | en_ZA |
| dc.description.uri | http://link.springer.com/journal/280 | en_ZA |
| dc.identifier.citation | Van Vuuren, RJ, Visagie, MH, Theron, AE & Joubert, AM 2015, 'Antimitotic drugs in the treatment of cancer', Cancer Chemotherapy and Pharmacology, vol. 76, no. 6, pp. 1101-1112. | en_ZA |
| dc.identifier.issn | 0344-5704 (print) | |
| dc.identifier.issn | 1432-0843 (online) | |
| dc.identifier.other | 10.1007/s00280-015-2903-8 | |
| dc.identifier.uri | http://hdl.handle.net/2263/51145 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | SpringerOpen | en_ZA |
| dc.rights | © The Author(s) 2015. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). | en_ZA |
| dc.subject | Taxanes | en_ZA |
| dc.subject | Epothilones | en_ZA |
| dc.subject | Vinca alkaloids | en_ZA |
| dc.subject | Estrogens | en_ZA |
| dc.subject | 2-Methoxyestradiol (2ME2) | en_ZA |
| dc.title | Antimitotic drugs in the treatment of cancer | en_ZA |
| dc.type | Article | en_ZA |