A review on the anti-hyperglycaemic potential of Catharanthus roseus and Portulacaria afra

Abstract

Diabetes mellitus is a prevalent non-communicable disease affecting individuals in developed and developing countries. However, low-income countries face significant challenges in managing diabetes due to socio-economic factors resulting in high mortality rates annually. The lack of adequate healthcare facilities and resources in low-income countries limits access to synthetic anti-hyperglycaemic medication, leading to an increased reliance on traditional medicinal plants to manage diabetes mellitus. One such traditional remedy is the combination of Catharanthus roseus (L.) G. Don and Portulacaria afra Jacq. (1:1) used by traditional healers in South Africa to lower blood glucose levels and manage diabetes symptoms. Catharanthus roseus has demonstrated anti-hyperglycaemic activity in diabetic-induced rats, while previous studies have identified various pharmacological potentials of P. afra, including anti-inflammatory and pain-relieving properties. This review aims to explore the anti-hyperglycaemic potential of C. roseus and P. afra in the context of their traditional use by South African healers. By examining the existing literature, we aim to provide insights into the potential of these medicinal plants as alternative and complementary treatments for diabetes management. As the global burden of diabetes continues to increase, it is critical to explore cost-effective and accessible treatments, particularly in low-income countries where healthcare resources are limited. This review contributes to the understanding of traditional medicinal plants' potential in the management of diabetes and provides a basis for further research into their use as alternative treatments.