Facile synthesis, characterization and in vitro antibacterial efficacy of functionalized 2-substituted benzimidazole motifs

dc.contributor.authorAjani, Olayinka Oyewale
dc.contributor.authorJoseph, Olaoluwasubomi Eneyeme
dc.contributor.authorIyaye, King Tamunodikibugerere
dc.contributor.authorOctober, Natasha
dc.contributor.authorAderohunmu, Damilola Victoria
dc.contributor.authorOlorunshola, Shade John
dc.contributor.authorAudu, Oluwatosin Yemisi
dc.date.accessioned2021-07-29T12:19:48Z
dc.date.available2021-07-29T12:19:48Z
dc.date.issued2020
dc.description.abstractA series of functionalized 2-substituted benzimidazole motifs was designed and successfully synthesized via thermal cyclization of 1,2-diaminobenzene on COOH end of L- leucine to achieve benzimidazole derivatives 6 as the essential precursor. The coupling of the precursor 6 with benzaldehyde derivatives a-h, ketone series i-k, and aryl sulfonyl chlorides l-n led to the formation of the targeted 2- substituted benzimidazole motifs 7a-n in improved yields. The targeted benzimidazole motifs were structurally authenticated through their spectral data and microanalytical parameters. The targeted final moieties were investigated for potential antimicrobial activity using the agar diffusion method with gentamicin as the clinical standard. All the compounds had a broad spectrum of activity with compound 7k having the highest remarkable activity with MIC of 0.98 ± 0.02 μg/mL and MBC value of 3.91 ± 0.10 μg/mL. These findings suggest that compound 7k containing camphor might be a good candidate for the design of new antimicrobial small-molecule drugs.en_ZA
dc.description.departmentChemistryen_ZA
dc.description.librarianpm2021en_ZA
dc.description.sponsorshipTWAS Research Granten_ZA
dc.description.urihttps://jurnal.ugm.ac.iden_ZA
dc.identifier.citationAjani, O.O., Joseph, O.E., Iya, K.T. et al. 2020, 'Facile synthesis, characterization and in vitro antibacterial efficacy of functionalized 2-substituted benzimidazole motifs', Indonesian Journal of Chemistry, vol. 20, no. 1. pp. 72 - 87.en_ZA
dc.identifier.issn14119420 (print)
dc.identifier.issn2460-1578 (online)
dc.identifier.other10.22146/ijc.40448
dc.identifier.urihttp://hdl.handle.net/2263/81057
dc.language.isoenen_ZA
dc.publisherChemistry Department, Universitas Gadjah Madaen_ZA
dc.rights© 2021 Indonesian Journal of Chemistry. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en_ZA
dc.subjectBenzimidazoleen_ZA
dc.subject[4+1]-cycloadditionen_ZA
dc.subjectSerial dilutionen_ZA
dc.subjectSAR studyen_ZA
dc.subjectAntibacterialen_ZA
dc.subjectStructure activity relationship (SAR)en_ZA
dc.titleFacile synthesis, characterization and in vitro antibacterial efficacy of functionalized 2-substituted benzimidazole motifsen_ZA
dc.typeArticleen_ZA

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