Phase behavior of the polymer/drug system PLA/DEET : effect of PLA molar mass on subambient liquid-liquid phase separation

dc.contributor.authorSungkapreecha, Chanita
dc.contributor.authorBeily, Mark J.
dc.contributor.authorKressler, Jörg
dc.contributor.authorFocke, Walter Wilhelm
dc.contributor.authorAndrosch, René
dc.date.accessioned2018-06-01T11:17:57Z
dc.date.issued2018-02
dc.description.abstractThe phase behavior of binary mixtures of non-crystallizable racemic poly (d, l-lactic acid) (PDLLA) and the mosquito-repellent/drug N,N-diethyl-3-methylbenzamide (DEET) was analyzed with respect to the effect of the polymer molar mass on the liquid-liquid (L–L) phase separation characteristics, by cloud-point measurements and differential scanning calorimetry. The PDLLA/DEET system shows a subambient upper critical solution temperature (UCST), with the critical temperature decreasing and critical polymer concentration increasing with decreasing molar mass of PDLLA. The obtained L–L phase separation curves were used to estimate the temperature-dependence of the interaction parameter, confirming that the enhanced miscibility of the system components in case of low molar mass PDLLA is due to increased entropy of mixing.en_ZA
dc.description.departmentChemical Engineeringen_ZA
dc.description.embargo2019-02-10
dc.description.librarianhj2018en_ZA
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG) (Grant AN 212/22).en_ZA
dc.description.urihttp://www.elsevier.com/locate/tcaen_ZA
dc.identifier.citationSungkapreecha, C., Beily, M.J., Kressler, J. et al. 2018, 'Phase behavior of the polymer/drug system PLA/DEET : effect of PLA molar mass on subambient liquid-liquid phase separation', Thermochimica Acta, vol. 660, pp. 77-81.en_ZA
dc.identifier.issn0040-6031 (print)
dc.identifier.issn1872-762X (online)
dc.identifier.other10.1016/j.tca.2017.12.021
dc.identifier.urihttp://hdl.handle.net/2263/65073
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2017 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Thermochimica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Thermochimica Acta, vol. 660, pp. 77-81, 2018. doi : 10.1016/j.tca.2017.12.021.en_ZA
dc.subjectPLA/DEET phase diagramen_ZA
dc.subjectLiquid-liquid phase separationen_ZA
dc.subjectFlory-Huggins interaction parameteren_ZA
dc.subjectPhase equilibriaen_ZA
dc.subjectPolystyreneen_ZA
dc.subjectScaffolden_ZA
dc.subjectFabricationen_ZA
dc.subjectDrug deliveryen_ZA
dc.subjectSolvent systemsen_ZA
dc.subjectMolecular weighten_ZA
dc.subjectMicroporous membrane formationen_ZA
dc.titlePhase behavior of the polymer/drug system PLA/DEET : effect of PLA molar mass on subambient liquid-liquid phase separationen_ZA
dc.typePostprint Articleen_ZA

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