Recurrent venous thrombosis – an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B

dc.contributor.authorLetete, N.
dc.contributor.authorVaz, Deborah
dc.contributor.authorMalishi, P.H.
dc.contributor.authorPotgieter, J.J.
dc.contributor.authorRheeder, Paul
dc.date.accessioned2025-06-27T05:18:22Z
dc.date.available2025-06-27T05:18:22Z
dc.date.issued2024-01
dc.description.abstractA 45-year-old female presented with unprovoked recurrent venous thromboembolism (VTE), in unusual sites, and pancytopenia, posing a complex diagnostic challenge. Work-up for inherited thrombophilia, antiphospholipid syndrome (APLS) and paroxysmal nocturnal haemoglobinuria were unremarkable. Investigations revealed autoimmune thyroid disease, and a mixed iron/vitamin B12 deficiency due to pernicious anaemia and resultant atrophic gastritis. Hyperhomocysteinaemia due to vitamin B12 deficiency was identified as a potential contributor to her recurrent VTE. This case highlights the unusual initial presentation of autoimmune polyendocrinopathy syndrome type 3B (APS-3B) with recurrent thromboembolism, and emphasises the importance of considering hyperhomocysteinaemia in unprovoked and atypical VTE cases.
dc.description.departmentHaematology
dc.description.departmentInternal Medicine
dc.description.librarianam2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.urihttp://www.samj.org.za/index.php/samj
dc.identifier.citationLetete, N., Vaz, D., Malishi, P.H. et al. 2024, 'Recurrent venous thrombosis – an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B', South African Medical Journal, vol. 114, no. 1, pp. 11-15. https://doi.org/10.7196/SAMJ.2024.v114i1.1477.
dc.identifier.issn0256-9574 (print)
dc.identifier.issn2078-5135 (online)
dc.identifier.other10.7196/SAMJ.2024.v114i1.1477
dc.identifier.urihttp://hdl.handle.net/2263/103013
dc.language.isoen
dc.publisherSouth African Medical Association
dc.rights© 2023 N Letete, D Vaz, P H Malishi, J J Pogieter, P Rheeder. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
dc.subjectHyperhomocysteinemia
dc.subjectAutoimmune polyendocrinopathy syndrome type 3B (APS-3B)
dc.subjectRecurrent thrombosis
dc.subjectVenous thromboembolism (VTE)
dc.subjectAntiphospholipid syndrome (APLS)
dc.titleRecurrent venous thrombosis – an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Letete_Recurrent_2024.pdf
Size:
144.65 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: