Recurrent venous thrombosis – an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B
dc.contributor.author | Letete, N. | |
dc.contributor.author | Vaz, Deborah | |
dc.contributor.author | Malishi, P.H. | |
dc.contributor.author | Potgieter, J.J. | |
dc.contributor.author | Rheeder, Paul | |
dc.date.accessioned | 2025-06-27T05:18:22Z | |
dc.date.available | 2025-06-27T05:18:22Z | |
dc.date.issued | 2024-01 | |
dc.description.abstract | A 45-year-old female presented with unprovoked recurrent venous thromboembolism (VTE), in unusual sites, and pancytopenia, posing a complex diagnostic challenge. Work-up for inherited thrombophilia, antiphospholipid syndrome (APLS) and paroxysmal nocturnal haemoglobinuria were unremarkable. Investigations revealed autoimmune thyroid disease, and a mixed iron/vitamin B12 deficiency due to pernicious anaemia and resultant atrophic gastritis. Hyperhomocysteinaemia due to vitamin B12 deficiency was identified as a potential contributor to her recurrent VTE. This case highlights the unusual initial presentation of autoimmune polyendocrinopathy syndrome type 3B (APS-3B) with recurrent thromboembolism, and emphasises the importance of considering hyperhomocysteinaemia in unprovoked and atypical VTE cases. | |
dc.description.department | Haematology | |
dc.description.department | Internal Medicine | |
dc.description.librarian | am2025 | |
dc.description.sdg | SDG-03: Good health and well-being | |
dc.description.uri | http://www.samj.org.za/index.php/samj | |
dc.identifier.citation | Letete, N., Vaz, D., Malishi, P.H. et al. 2024, 'Recurrent venous thrombosis – an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B', South African Medical Journal, vol. 114, no. 1, pp. 11-15. https://doi.org/10.7196/SAMJ.2024.v114i1.1477. | |
dc.identifier.issn | 0256-9574 (print) | |
dc.identifier.issn | 2078-5135 (online) | |
dc.identifier.other | 10.7196/SAMJ.2024.v114i1.1477 | |
dc.identifier.uri | http://hdl.handle.net/2263/103013 | |
dc.language.iso | en | |
dc.publisher | South African Medical Association | |
dc.rights | © 2023 N Letete, D Vaz, P H Malishi, J J Pogieter, P Rheeder. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. | |
dc.subject | Hyperhomocysteinemia | |
dc.subject | Autoimmune polyendocrinopathy syndrome type 3B (APS-3B) | |
dc.subject | Recurrent thrombosis | |
dc.subject | Venous thromboembolism (VTE) | |
dc.subject | Antiphospholipid syndrome (APLS) | |
dc.title | Recurrent venous thrombosis – an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B | |
dc.type | Article |