Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow

dc.contributor.authorWang, Simeng
dc.contributor.authorPanayides, Jenny-Lee
dc.contributor.authorRiley, Darren Lyall
dc.contributor.authorTighe, Christopher J.
dc.contributor.authorHellgardt, Klaus
dc.contributor.authorHii, King Kuok (Mimi)
dc.contributor.authorMiller, Philip W.
dc.date.accessioned2022-12-01T11:57:28Z
dc.date.available2022-12-01T11:57:28Z
dc.date.issued2021-09
dc.description.abstractThe functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate.en_US
dc.description.departmentChemistryen_US
dc.description.librarianhj2022en_US
dc.description.sponsorshipAn Imperial College London Research England GCRF Institutional Award.en_US
dc.description.urihttps://pubs.rsc.org/en/journals/journalissues/reen_US
dc.identifier.citationWang, S., Panayides, J.-L., Riley, D. et al. 2021, 'Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow', Reaction Chemistry and Engineering, vol. 6, no. 11, pp. 2018-2023, https://doi.org/10.1039/D1RE00343G.en_US
dc.identifier.issn2058-9883 (online)
dc.identifier.other10.1039/D1RE00343G
dc.identifier.urihttps://repository.up.ac.za/handle/2263/88586
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rights© The Royal Society of Chemistry 2021en_US
dc.subjectRapid formationen_US
dc.subjectEfficient formationen_US
dc.subject2-lithio-1-(triphenylmethyl)imidazoleen_US
dc.subjectSubstitution reactionsen_US
dc.subjectFlowen_US
dc.titleRapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flowen_US
dc.typePostprint Articleen_US

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