Clinicopathological study on experimental Trypanosoma brucei infections in horses. Part 2. Histopathological findings in the nervous system and other organs of treated and untreated horses reacting to nagana

dc.contributor.authorMcCully, R.M.
dc.contributor.authorNeitz, W.O.
dc.contributor.editorSouth Africa. Dept. of Agricultural Technical Services
dc.contributor.editorDe Lange, M.
dc.contributor.editorReinecke, R.K.
dc.contributor.editorWalker, Jane B.
dc.contributor.editorDe Kock, V.E.
dc.contributor.editorHowell, P.G.
dc.date.accessioned2015-11-30T08:31:05Z
dc.date.available2015-11-30T08:31:05Z
dc.date.created2015
dc.date.issued1971
dc.descriptionThe journals have been scanned in colour with a HP 5590 scanner; 600 dpi. Adobe Acrobat v.11 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.en_ZA
dc.description.abstractA detailed description of the histopathology of the nervous system and a brief account of lesions in visceral and other organs of six horses experimentally infected with Trypanosoma brucei Plimmer & Bradford, 1899 is given. Attempts to produce a chronic form of nagana in three horses by subcurative medications with Antrypol and Berenil were successful. The chronicity period was extended to 130 days in one and to approximately 9 months in the other two horses. The data on the histological findings on the three horses are listed in tabular form. The lesions in the central nervous system were characterized by a severe pleocytosis of the meninges, an extensive subpial gliosis corresponding in severity to the involvement of the overlying leptomeninges, segmental demyelination of optic tracts and some other areas of white matter as well as grey matter and extensive perivascular cuffing with lymphocytes, plasmocytes, large mononuclear and Mott cells in this order of descending frequency. Comparison between lesions of the acute form of human sleeping sickness and those of the experimentally produced chronic form of equine nagana revealed that points of similarity are far greater than those of dissimilarity. The latter include a lymphophagocytosis in the meninges and brain of man, a higher incidence of Mott cells in the meninges of horses and the penetration of trypanosomes in the brain of man which was not seen at this site in horses. With the exception of the pituitary of one horse, lesions of the nervous system of the remaining three horses were not striking. Histological changes in the visceral and other organs were neither pathognomonic nor of uniform occurrence.en_ZA
dc.identifier.citationMcCully, RM & Neitz, WO 1971, 'Clinicopathological study on experimental Trypanosoma brucei infections in horses. Part 2. Histopathological findings in the nervous system and other organs of treated and untreated horses reacting to nagana’, Onderstepoort Journal of Veterinary Research, vol. 38, no. 3, pp. 141-175.en_ZA
dc.identifier.urihttp://hdl.handle.net/2263/50996
dc.language.isoenen_ZA
dc.publisherPretoria : Government Printeren_ZA
dc.rights©South Africa. Dept. of Agricultural Technical Services (original). ©University of Pretoria. Dept. of Library Services (digital).en_ZA
dc.subjectVeterinary medicineen_ZA
dc.subjectSouth Africaen_ZA
dc.subject.lcshVeterinary medicine -- South Africa
dc.titleClinicopathological study on experimental Trypanosoma brucei infections in horses. Part 2. Histopathological findings in the nervous system and other organs of treated and untreated horses reacting to naganaen_ZA
dc.typeArticleen_ZA

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