The ins and outs of susceptibility testing for new b-lactam/b-lactamase inhibitor combinations for gram-negative organisms

dc.contributor.authorDingle, Tanis
dc.contributor.authorPitout, Johann D.D.
dc.date.accessioned2022-10-27T04:46:37Z
dc.date.available2022-10-27T04:46:37Z
dc.date.issued2022-07
dc.description.abstractCeftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam are among the newest b-lactam/b-lactamase inhibitors (BL/BLIs) introduced to the North American antibiotic market. All have broad Gram-negative activity, including against certain carbapenemases. Despite this, susceptibility testing is warranted due to variable activity against certain b-lactamases (e.g., oxacillinases) and the presence of acquired resistance mechanisms in some isolates. Here, we discuss what we know about these new antimicrobial agents and how to navigate implementation of susceptibility testing and reporting of these agents in clinical laboratories.en_US
dc.description.departmentMedical Microbiologyen_US
dc.description.urihttps://journals.asm.org/journal/jcmen_US
dc.identifier.citationDingle, T.C. & Pitout, J. The Ins and Outs of Susceptibility Testing for New β-Lactam/β-Lactamase Inhibitor Combinations for Gram-Negative Organisms. Journal of Clinical Microbiology 2022 Jul 20;60(7):e0080721. doi: 10.1128/jcm.00807-21.en_US
dc.identifier.issn0095-1137 (print)
dc.identifier.issn1098-660X (online)
dc.identifier.other10.1128/jcm.00807-21
dc.identifier.urihttps://repository.up.ac.za/handle/2263/87986
dc.language.isoenen_US
dc.publisherJournal of Clinical Microbiologyen_US
dc.rights© 2022 American Society for Microbiology. All Rights Reserved.en_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntimicrobial susceptibility testingen_US
dc.subjectB-lactamasesen_US
dc.subjectB-lactamsen_US
dc.subjectCarbapenemaseen_US
dc.subjectAntimicrobial resistance (AMR)en_US
dc.subjectB-lactam/b-lactamase inhibitors (BL/BLIs)en_US
dc.titleThe ins and outs of susceptibility testing for new b-lactam/b-lactamase inhibitor combinations for gram-negative organismsen_US
dc.typeArticleen_US

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