Effectiveness and knowledge, attitudes and practices of seasonal influenza vaccine in primary healthcare settings in South Africa, 2010-2013

dc.contributor.authorMcAnerney, Johanna M.
dc.contributor.authorWalaza, Sibongile
dc.contributor.authorCohen, Adam L.
dc.contributor.authorTempia, Stefano
dc.contributor.authorBuys, Amelia
dc.contributor.authorVenter, Marietjie
dc.contributor.authorBlumberg, Lucille Hellen
dc.contributor.authorDuque, Jazmin
dc.contributor.authorCohen, Cheryl
dc.date.accessioned2016-09-02T05:51:50Z
dc.date.available2016-09-02T05:51:50Z
dc.date.issued2015-10
dc.description.abstractOBJECTIVES : Influenza vaccine effectiveness (VE) and coverage data for sub-Saharan Africa are scarce. Using a test-negative case–control design, we estimated influenza VE annually among individuals with influenza-like illness presenting to an outpatient sentinel surveillance programme in South Africa from 2010 to 2013. A knowledge, attitudes and practices (KAP) influenza vaccine survey of programme clinicians was conducted in 2013. SAMPLE : In total, 9420 patients were enrolled in surveillance of whom 5344 (56.7%) were included in the VE analysis: 2678 (50.1%) were classified as controls (influenza test-negative) and 2666 (49.9%) as cases (influenza test-positive). RESULTS : Mean annual influenza vaccine coverage among controls was 4.5% for the four years. Annual VE estimates adjusted for age, underlying medical conditions and seasonality for 2010-2013 were 54.2% (95% confidence interval (CI): 2.4–78.6%), 57.1% (95% CI: 15.5–78.2%), 38.4% (95% CI: 71.7–78.1%) and 87.2% (95% CI: 67.2–95.0%), respectively. The KAP survey showed that >90% of clinicians were familiar with the indications for and the benefits of influenza vaccination. CONCLUSIONS : Our study showed that the vaccine was significantly protective in 2010, 2011 and 2013, but not in 2012 when the circulating A(H3N2) strain showed genetic drift. Vaccine coverage was low despite good clinician knowledge of vaccination indications. Further studies are needed to investigate the reason for the low uptake of influenza vaccine.en_ZA
dc.description.departmentMedical Virologyen_ZA
dc.description.librarianhb2016en_ZA
dc.description.sponsorshipThe programme forms part of the National Institute for Communicable Diseases core function and is not funded by external bodies.en_ZA
dc.description.urihttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1750-2659en_ZA
dc.identifier.citationMcAnerney, J, Walaza, S, Cohen, AL, Tempia, S, Buys, A, Venter, M, Blumberg, L, Duque, J & Cohen, C 2015, 'Effectiveness and knowledge, attitudes and practices of seasonal influenza vaccine in primary healthcare settings in South Africa, 2010-2013', Influenza and Other Respiratory Viruses, vol. 9, no. 3, pp. 143-150.en_ZA
dc.identifier.issn1750-2640 (print)
dc.identifier.issn1750-2659 (online)
dc.identifier.other10.1111/irv.12305
dc.identifier.urihttp://hdl.handle.net/2263/56582
dc.language.isoenen_ZA
dc.publisherWileyen_ZA
dc.rights© 2015 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License.en_ZA
dc.subjectAttitudesen_ZA
dc.subjectIllnessen_ZA
dc.subjectKnowledgeen_ZA
dc.subjectPracticesen_ZA
dc.subjectInfluenzaen_ZA
dc.subjectVaccine effectiveness (VE)en_ZA
dc.titleEffectiveness and knowledge, attitudes and practices of seasonal influenza vaccine in primary healthcare settings in South Africa, 2010-2013en_ZA
dc.typeArticleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
McAnerney_Effectiveness_2015.pdf
Size:
189.2 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: