Co-Circulation and Excretion Dynamics of Diverse Rubula- and Related Viruses in Egyptian Rousette Bats from South Africa

dc.contributor.authorMortlock, Marinda
dc.contributor.authorDietrich, Muriel
dc.contributor.authorWeyer, Jacqueline
dc.contributor.authorPaweska, Janusz Tadeusz
dc.contributor.authorMarkotter, Wanda
dc.date.accessioned2020-06-15T11:00:31Z
dc.date.available2020-06-15T11:00:31Z
dc.date.issued2019-01
dc.description.abstractThe Egyptian rousette bat (Rousettus aegyptiacus) has previously been implicated as the natural host of a zoonotic rubulavirus; however, its association with rubulaviruses has been studied to a limited extent. Urine, spleen, and other organs collected from the R. aegyptiacus population within South Africa were tested with a hemi-nested RT-PCR assay targeting a partial polymerase gene region of viruses from the Avula- and Rubulavirus genera. Urine was collected over a 14-month period to study the temporal dynamics of viral excretion. Diverse rubulaviruses, including viruses related to human mumps and parainfluenza virus 2, were detected. Active excretion was identified during two peak periods coinciding with the host reproductive cycle. Analysis of additional organs indicated co-infection of individual bats with a number of different putative rubulaviruses, highlighting the limitations of using a single sample type when determining viral presence and diversity. Our findings suggest that R. aegyptiacus can harbor a range of Rubula- and related viruses, some of which are related to known human pathogens. The observed peaks in viral excretion represents potential periods of a higher risk of virus transmission and zoonotic disease spill-over.en_ZA
dc.description.departmentBiochemistryen_ZA
dc.description.departmentGeneticsen_ZA
dc.description.departmentMedical Virologyen_ZA
dc.description.departmentMicrobiology and Plant Pathologyen_ZA
dc.description.librarianpm2020en_ZA
dc.description.urihttps://www.mdpi.com/journal/virusesen_ZA
dc.identifier.citationMortlock, M., Dietrich, M., Weyer, J. et al. 2019, 'Co-circulation and excretion dynamics of diverse Rubula- and related viruses in Egyptian rousette bats from South Africa', Viruses, vol, 11, no. 1, art, 37, pp. 1-21.en_ZA
dc.identifier.issn1999-4915 (online)
dc.identifier.other10.3390/v11010037
dc.identifier.urihttp://hdl.handle.net/2263/75000
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_ZA
dc.subjectParamyxovirusen_ZA
dc.subjectRubulavirusen_ZA
dc.subjectCo-circulationen_ZA
dc.subjectViral sheddingen_ZA
dc.subjectTissue distributionen_ZA
dc.subjectHuman mumps virus-relateden_ZA
dc.subjectHuman parainfluenza virus-relateden_ZA
dc.subjectExcretion dynamicsen_ZA
dc.subjectEgyptian rousette bat (Rousettus aegyptiacus)en_ZA
dc.titleCo-Circulation and Excretion Dynamics of Diverse Rubula- and Related Viruses in Egyptian Rousette Bats from South Africaen_ZA
dc.typeArticleen_ZA

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