Vectorial drivers of malaria transmission in Jabi Tehnan district, Amhara Regional State, Ethiopia

dc.contributor.authorBelay, Aklilu
dc.contributor.authorAsale, Abebe
dc.contributor.authorSole, Catherine L.
dc.contributor.authorKinya, Fiona
dc.contributor.authorYusuf, Abdullahi Ahmed
dc.contributor.authorTorto, Baldwyn
dc.contributor.authorMutero, Clifford Maina
dc.contributor.authorTchouassi, David P.
dc.date.accessioned2025-07-28T12:53:01Z
dc.date.available2025-07-28T12:53:01Z
dc.date.issued2024-06-13
dc.descriptionDATA AVAILABILITY : Sequences of mosquito specimens harbouring Plasmodium sporozoite infection were deposited in GenBank (PP419038- PP419052).
dc.description.abstractAmong the factors affecting the effectiveness of malaria control is poor knowledge of the entomologic drivers of the disease. We investigated anopheline populations as part of a baseline study to implement house screening of windows and doors as a supplementary malaria control tool towards elimination in Jabi Tehnan district, Amhara Regional State of Ethiopia. The samples were surveyed monthly using CDC light traps between June 2020 and May 2021. Mosquito trap density (< 3 mosquitoes/trap) was low, however, with a high overall Plasmodium sporozoite rate (9%; indoor = 4.3%, outdoor = 13.1%) comprising P. falciparum (88.9%) and P. vivax (11.1%). Anopheles gambiae s.l., mostly An. arabiensis, comprised > 80% of total anopheline captures and contributed ~ 42% of Plasmodium-infected mosquitoes. On the other hand, morphologically scored Anopheles funestus s.l., constituting about 6% of anopheline collections, accounted for 50% of sporozoite-infected mosquitoes. Most of the infected An. funestus s.l. specimens (86.7%) were grouped with previously unknown or undescribed Anopheles species previously implicated as a cryptic malaria vector in the western Kenyan highlands, confirming its wider geographic distribution in eastern Africa. Other species with Plasmodium infection included An. longipalpis C, An. theileri, An. demillioni, and An. nili. Cumulatively, 77.8% of the infected mosquitoes occurred outdoors. These results suggest efficient malaria parasite transmission despite the low vector densities, which has implications for effective endpoint indicators to monitor malaria control progress. Additionally, the largely outdoor infection and discovery of previously unknown and cryptic vectors suggest an increased risk of residual malaria transmission and, thus, a constraint on effective malaria prevention and control.
dc.description.departmentSchool of Health Systems and Public Health (SHSPH)
dc.description.departmentZoology and Entomology
dc.description.librarianam2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.sdgSDG-15: Life on land
dc.description.sponsorshipThe German Academic Exchange Service (DAAD) In-Region Postgraduate Scholarship under the African Regional Postgraduate Programme in Insect Science (ARPPIS) tenable at the International Centre of Insect Physiology and Ecology (icipe), Nairobi, Kenya, and a bursary award from the University of Pretoria as well. This study, conducted under the project Combatting Arthropod Pests for Better Health, Food, and Climate Resilience (CAP-Africa), was funded by the Norwegian Agency for Development Cooperation (Norad) (Grant number: RAF-3058 KEN-18/0005). Additional operational support for the study was provided by the Wellcome Trust International Intermediate Fellowship awarded to DPT (222005/Z/20/Z). We gratefully acknowledge the financial support for this research by the following organizations and agencies: the Swedish International Development Cooperation Agency (Sida); the Swiss Agency for Development and Cooperation (SDC); the Australian Centre for International Agricultural Research (ACIAR); the Norwegian Agency for Development Cooperation (Norad); the German Federal Ministry for Economic Cooperation and Development (BMZ); and the Government of the Republic of Kenya.
dc.description.urihttps://www.nature.com/srep/
dc.identifier.citationBelay, A.K., Asale, A., Sole, C.L. et al. 2024, 'Vectorial drivers of malaria transmission in Jabi Tehnan district, Amhara Regional State, Ethiopia', Scientific Reports, vol. 14, art. 13669, pp. 1-10. https://doi.org/10.1038/s41598-024-64436-3.
dc.identifier.issn2045-2322 (online)
dc.identifier.other10.1038/s41598-024-64436-3
dc.identifier.urihttp://hdl.handle.net/2263/103627
dc.language.isoen
dc.publisherNature Research
dc.rights© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License.
dc.subjectResidual malaria transmission
dc.subjectCryptic vectors
dc.subjectOutdoor biting
dc.subjectMalaria surveillance
dc.subjectHighland areas
dc.titleVectorial drivers of malaria transmission in Jabi Tehnan district, Amhara Regional State, Ethiopia
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Belay_Vectorial_2024.pdf
Size:
2.36 MB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: