Effect of cyclophosphamide on the acquisition of resistance to infestation by Rhipicephalus appendiculatus in rabbits
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Date
Authors
Binta, M.G.
Mushi, E.Z.
Rurangirwa, F.R.
Journal Title
Journal ISSN
Volume Title
Publisher
Published by the Agricultural Research Council, Onderstepoort Veterinary Institute
Abstract
Parenteral administration of cyclophosphamide in rabbits made resistant to infestation by the tick Rhipicephalus appendiculatus, resulted in abrogation of the resistance phenomenon. As a result, a high percentage (83%) of the larval ticks fed to repletion. This was in contrast to the control rabbits which were expressing the phenomenon of resistance to infestation by the ticks. In the latter, only 28% of the ticks fed to repletion. Cyclophosphamide administration in rabbits induced a leucopenia and depressed antibody response to the heterologous antigen, sheep red-blood cells.
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Keywords
Veterinary medicine, Cyclophosphamide, Effect, Infestation, Rabbits, Resistance, Rhipicephalus appendiculatus
Sustainable Development Goals
Citation
Binta, MG, Mushi, EZ & Rurangirwa, FR 1996, 'Effect of cyclophosphamide on the acquisition of resistance to infestation by Rhipicephalus appendiculatus in rabbits’. Onderstepoort Journal of Veterinary Research, vol. 63, no. 1, pp. 7-10.