Virus-host coexistence in phytoplankton through the genomic lens

dc.contributor.authorYau, Sheree
dc.contributor.authorKrasovec, Marc
dc.contributor.authorBenites, L. Felipe
dc.contributor.authorRombauts, Stephane
dc.contributor.authorGroussin, Mathieu
dc.contributor.authorVancaester, Emmelien
dc.contributor.authorAury, Jean-Marc
dc.contributor.authorDerelle, Evelyne
dc.contributor.authorDesdevises, Yves
dc.contributor.authorEscande, Marie-Line
dc.contributor.authorVan de Peer, Yves
dc.contributor.authorVandepoele, Klaas
dc.contributor.authorGourbiere, Sebastien
dc.contributor.authorPiganeau, Gwenael
dc.date.accessioned2021-04-14T05:02:09Z
dc.date.available2021-04-14T05:02:09Z
dc.date.issued2020-04-01
dc.description.abstractVirus-microbe interactions in the ocean are commonly described by “boom and bust” dynamics, whereby a numerically dominant microorganism is lysed and replaced by a virus-resistant one. Here, we isolated a microalga strain and its infective dsDNA virus whose dynamics are characterized instead by parallel growth of both the microalga and the virus. Experimental evolution of clonal lines revealed that this viral production originates from the lysis of a minority of virus-susceptible cells, which are regenerated from resistant cells. Whole-genome sequencing demonstrated that this resistant-susceptible switch involved a large deletion on one chromosome. Mathematical modeling explained how the switch maintains stable microalga-virus population dynamics consistent with their observed growth pattern. Comparative genomics confirmed an ancient origin of this “accordion” chromosome despite a lack of sequence conservation. Together, our results show how dynamic genomic rearrangements may account for a previously overlooked coexistence mechanism in microalgae-virus interactions.en_ZA
dc.description.departmentBiochemistryen_ZA
dc.description.departmentGeneticsen_ZA
dc.description.departmentMicrobiology and Plant Pathologyen_ZA
dc.description.librarianam2021en_ZA
dc.description.sponsorshipThe ANR grants, BOF project GOA 01G01715 and the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant.en_ZA
dc.description.urihttp://advances.sciencemag.orgen_ZA
dc.identifier.citationS. Yau, M. Krasovec, L. F. Benites, S. Rombauts, M. Groussin, E. Vancaester, J.-M. Aury, E. Derelle, Y. Desdevises, M.-L. Escande, N. Grimsley, J. Guy, H. Moreau, S. Sanchez-Brosseau, Y. van de Peer, K. Vandepoele, S. Gourbiere, G. Piganeau, Virus-host coexistence in phytoplankton through the genomic lens. Science Advances 6, eaay2587 (2020).en_ZA
dc.identifier.issn2375-2548 (online)
dc.identifier.other10.1126/sciadv.aay2587
dc.identifier.urihttp://hdl.handle.net/2263/79423
dc.language.isoenen_ZA
dc.publisherAmerican Association for the Advancement of Science:en_ZA
dc.rights© 2020 The Authors. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_ZA
dc.subjectOceanen_ZA
dc.subjectMicroorganismen_ZA
dc.subjectdsDNA virusen_ZA
dc.subjectVirus-susceptible cellsen_ZA
dc.titleVirus-host coexistence in phytoplankton through the genomic lensen_ZA
dc.typeArticleen_ZA

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