Severe mpox in an immunocompromised patient, South Africa 2024

dc.contributor.authorVardas, E.
dc.contributor.authorNaidoo, M.
dc.contributor.authorChopdat, N.A.I.
dc.contributor.authorWeyer, Jacqueline
dc.contributor.authorRanchod, A.I.
dc.contributor.authorMoosa, L.
dc.contributor.authorGlass, A.J.
dc.contributor.authorBlumberg, L.H.
dc.contributor.authorElsie, J.
dc.contributor.authorGaryson, W.
dc.contributor.authorPitjadi, T.M.
dc.contributor.authorKalla, Z.
dc.contributor.authorRanchod, A.
dc.date.accessioned2025-07-02T05:35:30Z
dc.date.available2025-07-02T05:35:30Z
dc.date.issued2024-10
dc.description.abstractA previously healthy 35-year-old male belonging to the men who have sex with men (MSM) community, practising both penetrative and receptive anal sex for the past 10 years, and with no travel history outside South Africa, presented initially with a prodrome of fever, sore throat, night sweats, myalgia and fatigue. A week after the onset of these nonspecific symptoms, the patient noted painless, non-pruritic skin lesions measuring 2 - 15 mm in diameter on the dorsum of his hands. Three days later he developed rigors, watery diarrhoea and similar lesions on his genital and perianal areas. A week later, the patient presented to the emergency department with extensive lesions encompassing almost his entire body. He was admitted with suspected mpox infection. Imaging showed extensive lymphadenopathy, and the diagnosis was confirmed by mpox polymerase chain reaction testing. During the admission, he was also newly diagnosed with HIV infection. Treatment with tecovirimat was initiated, and the patient recovered, albeit with significant depigmentation and scarring.
dc.description.departmentMedical Virology
dc.description.librarianam2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.sponsorshipThe whole genomic sequencing performed was funded by the operational budget of the NICD.
dc.description.urihttp://www.samj.org.za/index.php/samj
dc.identifier.citationVardas, E., Naidoo, M., Chopdat, N.A.I. et al. 2024, 'Severe mpox in an immunocompromised patient, South Africa 2024', South African Medical Journal, vol. 114, no. 10, pp. 33-37. https://doi.org/10.7196/SAMJ.2024.v114i10.2407.
dc.identifier.issn0256-9574 (print)
dc.identifier.issn2078-5135 (online)
dc.identifier.other10.7196/SAMJ.2024.v114i10.2407
dc.identifier.urihttp://hdl.handle.net/2263/103090
dc.language.isoen
dc.publisherSouth African Medical Association
dc.rights© E Vardas et al. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
dc.subjectMpox
dc.subjectSevere
dc.subjectHIV co-infection
dc.subjectImmunosuppressed
dc.subjectHuman immunodeficiency virus (HIV)
dc.subjectMen who have sex with men (MSM)
dc.titleSevere mpox in an immunocompromised patient, South Africa 2024
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Vardas_Severe_2024.pdf
Size:
5.37 MB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: