The production of immunity against Cl. welchii type B, Wilsdon. (The "Lamb dysentery bacillus")

dc.contributor.authorMason, J.H.
dc.contributor.editorDu Toit, P.J.
dc.date.accessioned2017-04-19T11:45:37Z
dc.date.available2017-04-19T11:45:37Z
dc.date.created2017
dc.date.issued1935
dc.descriptionThe articles have been scanned in colour with a HP Scanjet 5590;300dpi. adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.en_ZA
dc.description.abstractl. The total antitoxin binding value of a toxoid of Cl. welchii, Type B (the "lamb dysentery bacillus") has a direct bearing on its immunizing capacity. The more antitoxin a toxoid binds, the greater is the degree of immunity produced by it. 2. Atoxic toxoid, rendered slightly toxic by the addition of the toxins of Cl. welchii, Types A or B proved superior as an antigen to the toxoid itself. The addition of the toxin of Cl. septique did not increase the immunizing value of toxoids. 3. The intravenous injection of 4-6 sub-lethal doses of Type B toxin, within 4-5 hours may so immunize a guinea-pig that it resists a fatal dose of toxin 24 hours later. 4. Alum-precipitated toxoids proved, on the whole, inferior as antigens to the toxoids, themselves. The addition of agar, colloidal iron and saponin to toxoids did not increase their immunizing power. 5. The washed zinc chloride precipitates of toxoids proved superior as antigens to the toxoids themselves. The solubility of the precipitate appears to have a direct bearing on the degree of immunity produced. 6. Washed living or washed boiled suspensions of Type B bacilli (free from demonstrable toxin) stimulated the formation of antitoxin when injected into goats and guinea-pigs. 7. Washed suspensions of Type B bacilli, heated at 60⁰ C, for half-an-hour, contain a toxic material, not neutralizable by anti-toxin.en_ZA
dc.identifier.citationMason, JH 1935, 'The production of immunity against Cl. welchii Type B, Wilsdon. (The " Lamb dysentery bacillus")’, Onderstepoort Journal of Veterinary Science and Animal Industry, vol. 5,no. 2, pp. 391-416.en_ZA
dc.identifier.issn0330-2465
dc.identifier.urihttp://hdl.handle.net/2263/59985
dc.language.isoenen_ZA
dc.publisherPretoria : Government Printeren_ZA
dc.rights©South Africa, Dept. of Agricultural Technical Services (original). ©University of Pretoria, Dept. of Library Services (digital).en_ZA
dc.subjectVeterinary medicineen_ZA
dc.subject.lcshVeterinary medicine -- South Africa
dc.titleThe production of immunity against Cl. welchii type B, Wilsdon. (The "Lamb dysentery bacillus")en_ZA
dc.typeArticleen_ZA

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