Gastro-intestinal stromal tumours (GISTs) – the Pretoria experience and a literature review
dc.contributor.author | Hartley, R.J. | |
dc.contributor.author | Becker, J.H.R. (Hennie) | |
dc.contributor.author | Van der Walt, Hannes | |
dc.contributor.author | Luvhengo, T. | |
dc.date.accessioned | 2011-09-08T11:54:34Z | |
dc.date.available | 2011-09-08T11:54:34Z | |
dc.date.issued | 2011-08 | |
dc.description.abstract | AIM: To analyse the presentation and management of patients with gastro-intestinal stromal tumours (GISTs) at Pretoria hospitals. DESIGN: A retrospective study was done in which all available clinical records of primary c-KIT positive GISTs were analysed. SETTING: Secondary and tertiary care institutions in Pretoria, including both private and public hospitals. SUBJECTS: The population studied included all individuals treated at Pretoria hospitals from 17 July 2000 to 1 April 2009 who had a GIST confirmed with immunohistochemical c‑KIT staining. Patients with incomplete or inaccessible clinical records were excluded. OUTCOME MEASURES. Patient demographics including gender, age and race; presenting symptoms and signs; results of special investigations; and treatment. RESULTS: Fifty-four cases were identified for inclusion in the study. The age of the subjects ranged from 15 to 83 years. The male-to-female ratio was 1.5:1. The organ most commonly affected was the stomach, and abdominal pain and weight loss were the most common presenting symptoms. Seventy-six per cent of the patients were treated surgically, and 24% received imatinib. CONCLUSION: GISTs often present late with nonspecific symptoms, and are frequently discovered incidentally. Large tumours tend to be malignant. | en_US |
dc.description.uri | http://www.hmpg.co.za/journaldetail.php?journalno=8 | en_US |
dc.identifier.citation | Hartley, RJ, Becker, JHR, Van Der Walt, H & Luvhengo, T 2011, 'Gastro-intestinal stromal tumours (GISTs) – the Pretoria experience and a literature review', South African Journal of Surgery, vol. 49, no. 3, pp. 128-131. | en_US |
dc.identifier.issn | 0038-2361 | |
dc.identifier.uri | http://hdl.handle.net/2263/17245 | |
dc.language.iso | en | en_US |
dc.publisher | Health and Medical Publishing Group | en_US |
dc.rights | Health and Medical Publishing Group | en_US |
dc.subject | Gastro-intestinal stromal tumours (GISTs) | en_US |
dc.subject.lcsh | Gastrointestinal stromal tumors -- South Africa | en |
dc.title | Gastro-intestinal stromal tumours (GISTs) – the Pretoria experience and a literature review | en_US |
dc.type | Article | en_US |