Glycerol induces early fibrosis in regenerating rat skeletal muscle
| dc.contributor.author | Mahdy, Mohammed A.A. | |
| dc.contributor.author | Warita, Katsuhiko | |
| dc.contributor.author | Hosaka, Yoshinao Z. | |
| dc.date.accessioned | 2019-10-22T10:10:23Z | |
| dc.date.available | 2019-10-22T10:10:23Z | |
| dc.date.issued | 2018-10-02 | |
| dc.description.abstract | Glycerol has been recently used to induce muscle adiposity in mice. However, its effects on the rat muscles have not been investigated previously. Therefore, we investigated the regeneration outcomes of rat muscles following glycerol-induced injury at different time points. Glycerol injection induced myofiber degeneration with extensive inflammatory infiltration on day 4 followed by appearance of regenerating myotubes on day 7 after injury without adipocyte infiltration. Meanwhile, a significant collagen deposition at early stage of regeneration that increased together with persistent inflammatory infiltration up to day 14 after injury indicates impaired regeneration. In conclusion, glycerol injury in rats is more suitable as a fibrosis-inducing model than in mice due to earlier and higher accumulation of fibrous tissue with lacking adipogenesis. | en_ZA |
| dc.description.department | Anatomy and Physiology | en_ZA |
| dc.description.librarian | am2019 | en_ZA |
| dc.description.sponsorship | JSPS KAKENHI Grant Number 16H02585 and the Egyptian Government. | en_ZA |
| dc.description.uri | https://www.jstage.jst.go.jp | en_ZA |
| dc.identifier.citation | Mahdy M.A.A., Warita K., Hosaka Y.Z. 2018, 'Glycerol induces early fibrosis in regenerating rat skeletal muscle', Journal of Veterinary Medical Science, vol. 80, no. 11, 1646-1649. | en_ZA |
| dc.identifier.issn | 0916-7250 (print) | |
| dc.identifier.issn | 1347-7439 (online) | |
| dc.identifier.other | 10.1292/jvms.18-0328 | |
| dc.identifier.uri | http://hdl.handle.net/2263/71906 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | Maruzen Company Ltd | en_ZA |
| dc.rights | © 2018 The Japanese Society of Veterinary Science. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. | en_ZA |
| dc.subject | Fibrosis | en_ZA |
| dc.subject | Glycerol injury | en_ZA |
| dc.subject | Muscle regeneration | en_ZA |
| dc.subject | Rat | en_ZA |
| dc.title | Glycerol induces early fibrosis in regenerating rat skeletal muscle | en_ZA |
| dc.type | Article | en_ZA |