Chronic pancreatitis in dogs : a retrospective study of clinical, clinicopathological, and histopathological findings in 61 cases

dc.contributor.authorBostrom, Brier M.
dc.contributor.authorXenoulis, Panagiotis G.
dc.contributor.authorNewman, Shelley J.
dc.contributor.authorPool, Roy R.
dc.contributor.authorFosgate, Geoffrey Theodore
dc.contributor.authorSteiner, Jorg M.
dc.date.accessioned2013-02-22T08:17:23Z
dc.date.available2013-02-22T08:17:23Z
dc.date.issued2013-01
dc.description.abstractThe objective of the present study was to characterize the clinical, clinicopathologic, and histopathologic findings of dogs with chronic pancreatitis. The necropsy database at Texas A&M University was searched for reports of dogs with histologic evidence of chronic pancreatitis defined as irreversible histologic changes of the pancreas, i.e. fibrosis and atrophy. Medical records and necropsy reports were retrieved and reviewed. A reference necropsy population of 100 randomly selected dogs was used for signalment and concurrent disease comparisons. Cases were categorized as clinical or incidental chronic pancreatitis based on the presence of vomiting, decreased appetite, or both versus neither of these signs. All archived pancreata samples were evaluated histologically and scored using a published pancreatic scoring system. A total of 61 dogs with chronic pancreatitis were included in the study. The most frequent clinical signs were lethargy, decreased appetite, vomiting, and diarrhea. Compared to the reference necropsy population, chronic pancreatitis cases were more likely to be older, neutered, and of the non-sporting/toy breed group and to have concurrent endocrine, hepatobiliary, or neurologic diseases. Clinical chronic pancreatitis cases had significantly higher histological scores for pancreatic necrosis and peripancreatic fat necrosis. Clinical chronic pancreatitis cases were significantly more likely to have hepatobiliary or endocrine disease as well as increased liver enzyme activities, and cholesterol and bilirubin concentrations. In conclusion, clinical disease resulting from chronic pancreatitis might be related to the presence of pancreatic necrosis and pancreatic fat necrosis. The signalment, presentation, and concurrent diseases of dogs with chronic pancreatitis are similar to those previously reported for dogs with acute pancreatitis.en
dc.description.librarianam2013en
dc.description.librarianab2013
dc.description.urihttp://www.elsevier.com/locate/tvjlen
dc.identifier.citationBostrom, BM, Xenoulis, PG, Newman, SJ, Pool, RR, Fosgate, GT & Steiner, JM 2013, 'Chronic pancreatitis in dogs : a retrospective study of clinical, clinicopathological, and histopathological findings in 61 cases', Veterinary Journal, vol. 195, no. 1, p73-79.en
dc.identifier.issn1090-0233
dc.identifier.other10.1016/j.tvjl.2012.06.034
dc.identifier.other6603440077
dc.identifier.urihttp://hdl.handle.net/2263/21138
dc.language.isoenen
dc.publisherElsevieren
dc.relation.requiresAdobe Acrobat Readeren
dc.rights© 2012 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in The Veterinary Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in The Veterinary Journal, vol. 195, issue 1, Jan 2013, doi: 1016/j.tvjl.2012.06.034.en
dc.subjectCanineen
dc.subjectChronic pancreatitisen
dc.subjectPancreatic inflammationen
dc.subjectHistopathologyen
dc.subjectExocrine pancreatic diseaseen
dc.subject.lcshPancreatitisen
dc.subject.lcshDogs -- Diseasesen
dc.titleChronic pancreatitis in dogs : a retrospective study of clinical, clinicopathological, and histopathological findings in 61 casesen
dc.typePostprint Articleen

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