A stochastic model of the dynamics of HIV under a combination therapeutic intervention
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Date
Authors
Yadavalli, Venkata S. Sarma
Labeodan, Moremi Morire OreOluwapo
Udayabaskaran, Swaminathan
Mwanga, Y.A.
Journal Title
Journal ISSN
Volume Title
Publisher
Operations Research Society of SA
Abstract
Drug resistance to single therapeutic treatment in HIV infected individuals has promoted
research into combined treatments. In this paper we propose a stochastic model under
combined therapeutic treatment by extending the model of HIV pathogenesis under treatment
by anti-viral drugs given in [Perelson AS, Neumann AU, Markowits M, Leonard JM
& Ho DD, 1996, HIV-1 dynamics in vivo virion clearance rate, infected cell life span, and
viral generation time, Science New Series, 271, pp. 1582-1586]. Variance and co-variance
structures of variables are obtainable via this approach in addition to the mean numbers of
free HIV, infectious free HIV and non-infectious free HIV that were obtained by Perelson
et al. Comparing simulated data for before and after treatment indicates the importance of
combined treatment and its overall e ect(s).
Description
Keywords
Combined therapy, Drug resistance, Infectious free HIV, Stochastic model
Sustainable Development Goals
Citation
Yadavalli, VSS, Labeodan, MMO, Udayabaskaran, S & Mwanga, Y 2009, 'A stochastic model of the dynamics of HIV under a combination therapeutic intervention', Orion: Operations Research in South Africa, vol. 25, no. 1, pp. 17-30. [http://www.orssa.org.za/]