Clofibrate, a PPAR-alpha agonist, abrogates sodium fluoride-induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba-1/anti-calbindin signaling pathways

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Authors

Oyagbemi, Ademola A.
Adebiyi, Olamide E.
Adigun, Kabirat O.
Ogunpolu, Blessing Seun
Falayi, Olufunke Olubunmi
Hassan, Fasilat Oluwakemi
Folarin, Oluwabusayo R,
Adebayo, Adedeji K.
Adejumobi, Olumuyiwa Abiola
Asenuga, Ebunoluwa R.

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Publisher

Wiley

Abstract

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Keywords

Sodium fluoride (NaF), Oxidative stress, Neuroprotection, Neuroinflammation, Clofibrate, SDG-03: Good health and well-being

Sustainable Development Goals

Citation

Ademola A Oyagbemi, A.A., Adebiyi , O.E., Adigun, K.O., et al. Clofibrate, a PPAR-α agonist, abrogates sodium fluoride-induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba-1/anticalbindin signaling pathways. Environmental Toxicology. 2020; 35: 242–253. https://doi.org/10.1002/tox.22861.