Hypovitaminosis D in dogs with spirocercosis

dc.contributor.authorRosa, Chantal T.
dc.contributor.authorSchoeman, Johan P.
dc.contributor.authorMellanby, R.J.
dc.contributor.authorBerry, J.L.
dc.contributor.authorDvir, Eran
dc.date.accessioned2014-05-06T08:52:55Z
dc.date.available2014-09-30T00:20:07Z
dc.date.issued2013-09
dc.description.abstractBACKGROUND : Spirocercosis in dogs is characterized by esophageal nodules that can undergo neoplastic transformation. Hypovitaminosis D has been associated with neoplasia formation. We hypothesized hypovitaminosis D in neoplastic spirocercosis and that it could be a risk factor for neoplastic transformation. OBJECTIVE : To measure and compare vitamin D status, assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations in non-neoplastic (n = 25) and neoplastic (n = 26) spirocercosis client-owned dogs and healthy dogs (n = 24). ANIMALS : Twenty-five non-neoplastic dogs, 26 neoplastic dogs, and 24 healthy dogs. METHODS : Fifty-one dogs were randomly selected from 119 dogs diagnosed with spirocercosis presenting to our hospital, and further divided into non-neoplastic or neoplastic groups. Exclusion criteria included dogs less than 1 year old, with concurrent diseases, received corticosteroids, or treated prophylactically for spirocercosis. Serum 25(OH)D concentration was measured by high-performance liquid chromatography. Spirocercosis dogs’ appetites were graded and compared. RESULTS : Serum 25(OH)D concentrations were significantly different among all groups (P < .001). 25-Hydroxyvitamin D concentrations were significantly lower in neoplastic group (median 30.7 nmol/L [range 14.7–62.2]) compared to nonneoplastic (median 52.7 nmol/L [range 19.1–129.7, P < .05]) and healthy groups (median 74.6 nmol/L [range 37.4–130.5, P < .005]). 25-hydroxyvitamin D concentrations were significantly lower in non-neoplastic spirocercosis dogs compared to healthy ones (P < .05). Neoplastic and non-neoplastic spirocercosis dogs had similar appetite scores (P = 1.0). 25- Hydroxyvitamin D concentrations were not significantly different between dogs with normal (P = .087) and abnormal (P = .125) appetites within neoplastic and non-neoplastic spirocercosis groups. CONCLUSIONS AND CLINICAL IMPORTANCE : Further studies are warranted to determine potential use of vitamin D treatment in spirocercosis and explore role of hypovitaminosis D in pathogenesis of malignant transformation.en
dc.description.librarianhb2014en
dc.description.librarianmn2014
dc.description.urihttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1939-1676en
dc.identifier.citationRosa, CT, Schoeman, JP, Berry, JL, Mellanby, RJ & Dvir, E 2013, 'Hypovitaminosis D in dogs with spirocercosis', Journal of Veterinary Internal Medicine, vol. 27, no. 5, pp. 1159-1164.en
dc.identifier.issn0891-6640 (print)
dc.identifier.issn1939-1679 (online)
dc.identifier.other10.1111/jvim.12161
dc.identifier.other7005814117
dc.identifier.other7004445917
dc.identifier.otherJ-6765-2013
dc.identifier.urihttp://hdl.handle.net/2263/39713
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rights© 2013 by the American College of Veterinary Internal Medicine.The definite version is available at : http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1939-1676en
dc.subjectCalcidioen
dc.subjectNeoplasiaen
dc.subjectVitamin Den
dc.subjectCanine spirocercosisen
dc.subjectDogsen
dc.subject.lcshDogs -- Diseasesen
dc.titleHypovitaminosis D in dogs with spirocercosisen
dc.typePostprint Articleen

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