Combined 18F-Fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy : results of an international multicenter trial

dc.contributor.authorIagaru, Andrei
dc.contributor.authorMittra, Erik
dc.contributor.authorMosci, Camila
dc.contributor.authorDick, David W.
dc.contributor.authorSathekge, Mike Machaba
dc.contributor.authorPrakash, Vineet
dc.contributor.authorIyer, Victor
dc.contributor.authorLapa, Paula
dc.contributor.authorIsidoro, Jorge
dc.contributor.authorDe Lima, Joao M.
dc.contributor.authorGambhir, Sanjiv Sam
dc.date.accessioned2013-03-27T06:29:09Z
dc.date.available2013-03-27T06:29:09Z
dc.date.issued2013-02-14
dc.description.abstract(18)F-FDG PET/CT is used in a variety of cancers, but because of variable rates of glucose metabolism, not all cancers are reliably identified. (18)F(-) PET/CT allows for the acquisition of highly sensitive and specific images of the skeleton. We prospectively evaluated combined (18)F(-)/(18)F-FDG as a single PET/CT examination for evaluation of cancer patients and compared it with separate (18)F(-) PET/CT and (18)F-FDG PET/CT scans. METHODS: One hundred fifteen participants with cancer were prospectively enrolled in an international multicenter trial evaluating (18)F(-) PET/CT, (18)F-FDG PET/CT, and combined (18)F(-)/(18)F-FDG PET/CT. The 3 PET/CT scans were performed sequentially within 4 wk of one another for each patient. RESULTS: (18)F(-)/(18)F-FDG PET/CT allowed for accurate interpretation of radiotracer uptake outside the skeleton, with findings similar to those of (18)F-FDG PET/CT. In 19 participants, skeletal disease was more extensive on (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT than on (18)F-FDG PET/CT. In another 29 participants, (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT showed osseous metastases where (18)F-FDG PET/CT was negative. The extent of skeletal lesions was similar in 18 participants on all 3 scans. CONCLUSION: This trial demonstrated that combined (18)F(-)/(18)F-FDG PET/CT shows promising results when compared with separate (18)F(-) PET/CT and (18)F-FDG PET/CT for evaluation of cancer patients. This result opens the possibility for improved patient care and reduction in health-care costs, as will be further evaluated in future trials.en_US
dc.description.librarianam2013en_US
dc.description.librarianay2013
dc.description.sponsorshipThe ClinicalTrials.gov identifier for this study is NCT00725387.en_US
dc.description.urihttp://jnm.snmjournals.org/en_US
dc.identifier.citationIagaru, A, Mittra, E, Mosci, C, Dick, DW, Sathekge, M, Prakash, V, Iyer, V, Lapa, P, Isidoro, J, De Lima, JM & Gambhir, SS 2013, 'Combined 18F-Fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy : results of an international multicenter trial', Journal of Nuclear Medicine, vol. 54, no. 2, pp. 176-183.en_US
dc.identifier.issn0161-5505 (print)
dc.identifier.issn2159-662X (online)
dc.identifier.other10.2967/jnumed.112.108803
dc.identifier.urihttp://hdl.handle.net/2263/21216
dc.language.isoenen_US
dc.publisherSociety of Nuclear Medicine, Inc.en_US
dc.rights© 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc. This research was originally published in JNM. Author(s). Title. JNM. Year;vol:pp-pp.en_US
dc.subject18F-en_US
dc.subject18F-FDGen_US
dc.subjectPET/CTen_US
dc.subjectCanceren_US
dc.subject.lcshCancer -- Patients -- Careen
dc.subject.lcshSkeleton -- Radiography -- Research
dc.titleCombined 18F-Fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy : results of an international multicenter trialen_US
dc.typeArticleen_US

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