Combined 18F-Fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy : results of an international multicenter trial
dc.contributor.author | Iagaru, Andrei | |
dc.contributor.author | Mittra, Erik | |
dc.contributor.author | Mosci, Camila | |
dc.contributor.author | Dick, David W. | |
dc.contributor.author | Sathekge, Mike Machaba | |
dc.contributor.author | Prakash, Vineet | |
dc.contributor.author | Iyer, Victor | |
dc.contributor.author | Lapa, Paula | |
dc.contributor.author | Isidoro, Jorge | |
dc.contributor.author | De Lima, Joao M. | |
dc.contributor.author | Gambhir, Sanjiv Sam | |
dc.date.accessioned | 2013-03-27T06:29:09Z | |
dc.date.available | 2013-03-27T06:29:09Z | |
dc.date.issued | 2013-02-14 | |
dc.description.abstract | (18)F-FDG PET/CT is used in a variety of cancers, but because of variable rates of glucose metabolism, not all cancers are reliably identified. (18)F(-) PET/CT allows for the acquisition of highly sensitive and specific images of the skeleton. We prospectively evaluated combined (18)F(-)/(18)F-FDG as a single PET/CT examination for evaluation of cancer patients and compared it with separate (18)F(-) PET/CT and (18)F-FDG PET/CT scans. METHODS: One hundred fifteen participants with cancer were prospectively enrolled in an international multicenter trial evaluating (18)F(-) PET/CT, (18)F-FDG PET/CT, and combined (18)F(-)/(18)F-FDG PET/CT. The 3 PET/CT scans were performed sequentially within 4 wk of one another for each patient. RESULTS: (18)F(-)/(18)F-FDG PET/CT allowed for accurate interpretation of radiotracer uptake outside the skeleton, with findings similar to those of (18)F-FDG PET/CT. In 19 participants, skeletal disease was more extensive on (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT than on (18)F-FDG PET/CT. In another 29 participants, (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT showed osseous metastases where (18)F-FDG PET/CT was negative. The extent of skeletal lesions was similar in 18 participants on all 3 scans. CONCLUSION: This trial demonstrated that combined (18)F(-)/(18)F-FDG PET/CT shows promising results when compared with separate (18)F(-) PET/CT and (18)F-FDG PET/CT for evaluation of cancer patients. This result opens the possibility for improved patient care and reduction in health-care costs, as will be further evaluated in future trials. | en_US |
dc.description.librarian | am2013 | en_US |
dc.description.librarian | ay2013 | |
dc.description.sponsorship | The ClinicalTrials.gov identifier for this study is NCT00725387. | en_US |
dc.description.uri | http://jnm.snmjournals.org/ | en_US |
dc.identifier.citation | Iagaru, A, Mittra, E, Mosci, C, Dick, DW, Sathekge, M, Prakash, V, Iyer, V, Lapa, P, Isidoro, J, De Lima, JM & Gambhir, SS 2013, 'Combined 18F-Fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy : results of an international multicenter trial', Journal of Nuclear Medicine, vol. 54, no. 2, pp. 176-183. | en_US |
dc.identifier.issn | 0161-5505 (print) | |
dc.identifier.issn | 2159-662X (online) | |
dc.identifier.other | 10.2967/jnumed.112.108803 | |
dc.identifier.uri | http://hdl.handle.net/2263/21216 | |
dc.language.iso | en | en_US |
dc.publisher | Society of Nuclear Medicine, Inc. | en_US |
dc.rights | © 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc. This research was originally published in JNM. Author(s). Title. JNM. Year;vol:pp-pp. | en_US |
dc.subject | 18F- | en_US |
dc.subject | 18F-FDG | en_US |
dc.subject | PET/CT | en_US |
dc.subject | Cancer | en_US |
dc.subject.lcsh | Cancer -- Patients -- Care | en |
dc.subject.lcsh | Skeleton -- Radiography -- Research | |
dc.title | Combined 18F-Fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy : results of an international multicenter trial | en_US |
dc.type | Article | en_US |