A case of paroxysmal nocturnal hemoglobinuria (PNH) in an obstetric patient : a South African perspective

dc.contributor.authorLaudin, Garrick
dc.contributor.authorWium, Lizemarie
dc.date.accessioned2020-07-24T14:12:31Z
dc.date.available2020-07-24T14:12:31Z
dc.date.issued2019-01-16
dc.description.abstractParoxysmal Nocturnal Hemoglobinuria (PNH) originates from an acquired genetic defect in a multipotent hematopoietic stem cell that becomes stem-cell-like in its ability to survive, expand, and self-renew. PNH is a rare condition characterized by intravascular hemolysis. PNH can arise anew or in the setting of an underlying bone marrow disorder such as aplastic anemia (AA), myelodysplastic syndrome (MDS), or primary myelofibrosis (PMF). This case presentation documents the challenging diagnosis of PNH in the obstetric setting, in which other possible causes for a hemolytic anemia could be considered. We discuss the management of a pregnancy in the presence of PNH in a low-to-middle income setting.en_ZA
dc.description.departmentInternal Medicineen_ZA
dc.description.librarianam2020en_ZA
dc.description.urihttps://journals.seedmedicalpublishers.com/index.php/cmien_ZA
dc.identifier.citationLaudin, G. & Wium, L. 2019, 'A case of paroxysmal nocturnal hemoglobinuria (PNH) in an obstetric patient: a South African perspective', Clinical Management Issues, vol. 13, no. 1, pp. 1-5.en_ZA
dc.identifier.issn1973-4832 (print)
dc.identifier.issn2283-3137 (online)
dc.identifier.other0.7175/cmi.v13i1.1392
dc.identifier.urihttp://hdl.handle.net/2263/75428
dc.language.isoenen_ZA
dc.publisherSEEd Medical Publishersen_ZA
dc.rights© 2019 The Authors. Published by SEEd srl. This is an open access article under the CC BY-NC 4.0 license.en_ZA
dc.subjectHemoglobinuriaen_ZA
dc.subjectParoxysmalen_ZA
dc.subjectAnemiaen_ZA
dc.subjectObstetricsen_ZA
dc.subjectParoxysmal nocturnal hemoglobinuria (PNH)en_ZA
dc.subjectPrimary myelofibrosis (PMF)en_ZA
dc.subjectBone marrow disorderen_ZA
dc.subjectAplastic anemia (AA)en_ZA
dc.subjectSouth Africa (SA)en_ZA
dc.titleA case of paroxysmal nocturnal hemoglobinuria (PNH) in an obstetric patient : a South African perspectiveen_ZA
dc.typeArticleen_ZA

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