Effects of non-thermal mobile phone radiation on breast adenocarcinoma cells

dc.contributor.authorStander, Barend Andre
dc.contributor.authorMarais, Sumari
dc.contributor.authorHuyser, Carin
dc.contributor.authorFourie, Zen
dc.contributor.authorLeszczynski, Dariusz
dc.contributor.authorJoubert, Annie M.
dc.date.accessioned2011-10-07T14:15:54Z
dc.date.available2011-10-07T14:15:54Z
dc.date.issued2011-09-14
dc.description.abstractMobile phone usage currently exceeds landline communication in Africa. The extent of this usage has raised concerns about the long-term health effects of the ongoing use of mobile phones. To assess the physiological effects of radiation from mobile phones in vitro, MCF-7 breast adenocarcinoma cells were exposed to 2W/kg non-thermal 900-MHz mobile phone radiation. The effects investigated were those on metabolic activity, cell morphology, cell cycle progression, phosphatidylserine (PS) externalisation and the generation of reactive oxygen species and nitrogen species. Statistically insignificant increases in mitochondrial dehydrogenase activity were observed in irradiated cells when compared to controls. Fluorescent detection of F-actin demonstrated an increase in F-actin stress fibre formation in irradiated MCF-7 cells. Cell cycle progression revealed no statistically significant variation. A small increase in early and late apoptotic events in irradiated MCF-7 cells was observed. No statistically significant changes were observed in reactive oxygen and reactive nitrogen species generation. In addition, quantitative and qualitative analyses of cell cycle activity and nuclear and cytosolic changes, respectively, revealed no significant changes. In conclusion, exposure to 1 h of 900-MHz irradiation induced an increase in PS externalisation and an increase in the formation of F-actin stress fibres in MCF-7 cells. Data obtained from this study, and their correlation with other studies, provides intriguing links between radio frequency radiation and cellular events and warrant further investigation.en_US
dc.description.sponsorshipThis research was supported by grants from the Medical Research Council of South Africa (AG374, AK076), the Cancer Association of South Africa (AK246), the Struwig- Germeshuysen Cancer Research Trust of South Africa (AJ038, AN074) and the South African Bureau of Standards (AK386, AK387).en_US
dc.description.urihttp://www.sajs.co.zaen_US
dc.identifier.citationStander BA, Marais S, Huyser C, Fourie Z, Leszczynski D, Joubert AM. Effects of non-thermal mobile phone radiation on breast adenocarcinoma cells. S Afr J Sci. 2011;107(9/10), Art. #525, 9 pages. [Doi: 10.4102/sajs.v107i9/10.525]en_US
dc.identifier.issn0038-2353
dc.identifier.issn1996-7489 (online)
dc.identifier.other10.4102/sajs.v107i9/10.525
dc.identifier.urihttp://hdl.handle.net/2263/17410
dc.language.isoenen_US
dc.publisherAcademy of Science of South Africaen_US
dc.rights© 2011. The Authors. Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License.en_US
dc.subjectNon-thermal mobile phone radiationen_US
dc.subjectBreast adenocarcinoma cellsen_US
dc.subject.lcshCell phones -- Researchen
dc.subject.lcshRadiation -- Researchen
dc.titleEffects of non-thermal mobile phone radiation on breast adenocarcinoma cellsen_US
dc.typeArticleen_US

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