Neuropathic pain - current concepts

dc.contributor.authorMeyer, Helgard Pieter
dc.date.accessioned2008-08-06T09:12:57Z
dc.date.available2008-08-06T09:12:57Z
dc.date.issued2008-05
dc.description.abstractNeuropathic pain (NP) represents a common and diverse group of disorders with peripheral and/or central nervous system damage or dysfunction. Many patients report intractable and severe pain that is resistant to simple analgesics. The diagnosis of NP is primarily based on clinical evaluation rather than diagnostic tests. Distinct pain qualities in the patient’s history and findings on clinical examination, such as hyperalgesia and other sensory findings in an area correlating with the patient’s pain pattern are important in diagnosis. Various screening tools may assist in the diagnosis of NP. A number of pathophysiological mechanisms have been identified in NP, including sodium- and calcium-channel upregulation and spinal cord hyperexcitability (central sensitisation).Appropriate management includes evaluation of the functional impact of NP, patient education and reassurance. A multi-model biopsychosocial approach that includes various nonpharmacological modalities is recommended. Appropriate pharmacological management is based on evidence-based recommendations that provide guidance for selecting first-, second- and third-line medications, alone or in combination. It is hoped that future treatment advances will improve the care of patients who live with NP.en
dc.format.extent333350 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationMeyer, HP 2008, 'Neuropathic pain - current concepts', South African Family Practice, vol. 50, no. 3, pp. 40-49. [www.safpj.co.za]en
dc.identifier.issn1726-426X
dc.identifier.urihttp://hdl.handle.net/2263/6495
dc.language.isoenen
dc.publisherMedpharm Publicationsen
dc.rightsMedpharm Publicationsen
dc.subjectNeuropathic painen
dc.subjectCurrent conceptsen
dc.subjectCentral nervous system damageen
dc.subjectCentral nervous system disordersen
dc.subjectPeripheral nervesen
dc.subjectSevere painen
dc.subjectPainen
dc.subjectIntractable painen
dc.subjectClinical evaluationen
dc.subjectClinical diagnosisen
dc.subjectPathophysiologyen
dc.subjectSodium-channel upregulationen
dc.subjectCalcium-channel upregulationen
dc.subjectSpinal cord hyperexcitabilityen
dc.subjectPatient educationen
dc.subjectBiopsychosocial approachen
dc.subjectPharmacological treatmenten
dc.subjectManagementen
dc.subjectTreatmenten
dc.subjectNon-pharmacological treatmenten
dc.subjectCombination therapyen
dc.subjectEtiologyen
dc.subjectEpidemiologyen
dc.subjectTigeminal neuralgiaen
dc.subjectDiabetic polyneuropathyen
dc.subjectPostherpetic neuralgiaen
dc.subjectPolyneuropathyen
dc.subjectRegional pain syndromeen
dc.subject.lcshCentral nervous system--Diseases
dc.subject.lcshCentral pain
dc.subject.lcshNerves, Peripheral--Diseases -- Diagnosis
dc.subject.lcshHyperalgesia
dc.subject.lcshDrugs--Dose-response relationship
dc.subject.lcshDrugs--Effectiveness
dc.titleNeuropathic pain - current conceptsen
dc.typeArticleen

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Meyer_Neuropathic(2008).pdf
Size:
325.54 KB
Format:
Adobe Portable Document Format

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
2.4 KB
Format:
Item-specific license agreed upon to submission
Description: