Correlation between [68Ga]Ga-FAPI-46 PET imaging and HIF-1 immunohistochemical analysis in cervical cancer: proof-of-concept

dc.contributor.authorMokoala, Kgomotso M.G.
dc.contributor.authorLawal, Ismaheel Opeyemi
dc.contributor.authorMaserumule, Letjie C.
dc.contributor.authorBida, Meshack
dc.contributor.authorMaes, Alex
dc.contributor.authorNdlovu, Honest
dc.contributor.authorReed, Janet D.
dc.contributor.authorMahapane, Johncy
dc.contributor.authorDavis, Cindy
dc.contributor.authorVan de Wiele, Christophe
dc.contributor.authorPopoola, Gbenga
dc.contributor.authorGiesel, Frederik L.
dc.contributor.authorVorster, Mariza
dc.contributor.authorSathekge, Mike Machaba
dc.contributor.emailmike.sathekge@up.ac.zaen_US
dc.date.accessioned2024-04-18T12:54:55Z
dc.date.available2024-04-18T12:54:55Z
dc.date.issued2023-08-03
dc.descriptionDATA AVAILABILITY STATEMENT : The data presented in this study are available on request from the corresponding author. The data are not publicly available due to limited space for the manucrsipt.en_US
dc.descriptionCONFLICTS OF INTEREST : Frederik L. Giesel has a patent application for quinolone-based FAP-targeting agents for imaging and therapy. He also has shares of a consultancy group for iTheranostics and is also a medical advisor for ABX Advanced Biochemical Compound, Sofie Biosciences, Telix Pharmaceuticals, and Alpha Fusion. The other authors have no relevant financial or non-financial interests to disclose.en_US
dc.description.abstractHypoxia leads to changes in tumor microenvironment (upregulated CAFs) with resultant aggressiveness. A key factor in the physiological response to hypoxia is hypoxia-inducible factor-1alpha (HIF-1 ). [68Ga]Ga-FAPI PET imaging has been demonstrated in various cancer types. We hypothesized that [68Ga]Ga-FAPI PET may be used as an indirect tracer for mapping hypoxia by correlating the image findings to pathological analysis of HIF-1 expression. The [68Ga]Ga- FAPI PET/CT scans of women with cancer of the cervix were reviewed and the maximum and mean standardized uptake value (SUVmax and SUVmean) and FAPI tumor volume (FAPI-TV) were documented. Correlation analysis was performed between PET-derived parameters and immunohistochemical staining as well as between PET-derived parameters and the presence of metastasis. Ten women were included. All patients demonstrated tracer uptake in the primary site or region of the primary. All patients had lymph node metastases while only six patients had distant visceral or skeletal metastases. The mean SUVmax, SUVmean, and FAPI-TV was 18.89, 6.88, and 195.66 cm3, respectively. The average FAPI-TV for patients with additional sites of metastases was higher than those without. Immunohistochemistry revealed varying intensities of HIF-1a expression in all tested samples. There was a positive correlation between the presence of skeletal metastases and staining for HIF-1a (r = 0.80; p = 0.017). The presence of skeletal metastasis was correlated to the HIF-1a staining (percentage distribution). Furthermore, the FAPI-TV was a better predictor of metastatic disease than the SUVmax.en_US
dc.description.departmentNuclear Medicineen_US
dc.description.departmentRadiographyen_US
dc.description.librarianam2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.urihttps://www.mdpi.com/journal/cancersen_US
dc.identifier.citationMokoala, K.M.G.; Lawal, I.O.; Maserumule, L.C.; Bida, M.; Maes, A.; Ndlovu, H.; Reed, J.; Mahapane, J.; Davis, C.; Van deWiele, C.; et al. Correlation between [68Ga]Ga-FAPI-46 PET Imaging and HIF-1 Immunohistochemical Analysis in Cervical Cancer: Proof-of-Concept. Cancers 2023, 15, 3953. https://DOI.org/10.3390/cancers15153953.en_US
dc.identifier.issn2072-6694 (online)
dc.identifier.other10.3390/cancers15153953
dc.identifier.urihttp://hdl.handle.net/2263/95660
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_US
dc.subject[68Ga]Ga-FAPI PET/CTen_US
dc.subjectCervical canceren_US
dc.subjectImmunohistochemistryen_US
dc.subjectPositron emission tomography/computed tomography (PET/CT)en_US
dc.subjectHypoxiaen_US
dc.subjectHypoxia-inducible factor-1alpha (HIF-1)en_US
dc.subjectFAPI tumor volume (FAPI-TV)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleCorrelation between [68Ga]Ga-FAPI-46 PET imaging and HIF-1 immunohistochemical analysis in cervical cancer: proof-of-concepten_US
dc.typeArticleen_US

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