Interactions of antibiotics and methanolic crude extracts of Afzelia Africana (Smith.) against drug resistance bacterial isolates

dc.contributor.authorAiyegoro, Olayinka
dc.contributor.authorAdewusi, Emmanuel Adekanmi
dc.contributor.authorOyedemi, Sunday
dc.contributor.authorAkinpelu, David
dc.contributor.authorOkoh, Anthony
dc.date.accessioned2011-09-30T06:17:17Z
dc.date.available2011-09-30T06:17:17Z
dc.date.issued2011-07-13
dc.description.abstractInfection due to multidrug resistance pathogens is difficult to manage due to bacterial virulence factors and because of a relatively limited choice of antimicrobial agents. Thus, it is imperative to discover fresh antimicrobials or new practices that are effective for the treatment of infectious diseases caused by drug-resistant microorganisms. The objective of this experiment is to investigate for synergistic outcomes when crude methanolic extract of the stem bark of Afzelia africana and antibiotics were combined against a panel of antibiotic resistant bacterial strains that have been implicated in infections. Standard microbiological protocols were used to determine the minimum inhibitory concentrations (MICs) of the extract and antibiotics, as well as to investigate the effect of combinations of the methanolic extract of A. africana stem bark and selected antibiotics using the time-kill assay method. The extract of Afzelia africana exhibited antibacterial activities against both Gram-negative and Gram-positive bacteria made up of environmental and standard strains at a screening concentration of 5 mg/mL. The MICs of the crude extracts and the antibiotics varied between 1 μg/mL and 5.0 mg/mL. Overall, synergistic response constituted about 63.79% of all manner of combinations of extract and antibiotics against all test organisms; antagonism was not detected among the 176 tests carried out. The extract from A. africana stem bark showed potentials of synergy in combination with antibiotics against strains of pathogenic bacteria. The detection of synergy between the extract and antibiotics demonstrates the potential of this plant as a source of antibiotic resistance modulating compounds.en_US
dc.description.urihttp://www.mdpi.com/journal/ijmsen_US
dc.identifier.citationAiyegoro, O, Adewusi, A, Oyedemi, S, Akinpelu, D & Okoh, A 2011, 'Interactions of antibiotics and methanolic crude extracts of Afzelia Africana (Smith.) against drug resistance bacterial isolates', International Journal of Molecular Sciences, vol. 12, no. 7, pp. 4477-4487.en_US
dc.identifier.issn1422-0067
dc.identifier.other10.3390/ijms12074477
dc.identifier.urihttp://hdl.handle.net/2263/17355
dc.language.isoenen_US
dc.publisherMDPI Publishingen_US
dc.rights© 2011 by the author; licensee MDPI, Basel, Switzerland.; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).en_US
dc.subjectAfzelia Africanaen_US
dc.subjectSynergyen_US
dc.subjectAntibioticsen_US
dc.subjectExtracten_US
dc.subjectDrug-resistanten_US
dc.subjectMicroorganismsen_US
dc.subject.lcshDrug resistance -- Researchen
dc.titleInteractions of antibiotics and methanolic crude extracts of Afzelia Africana (Smith.) against drug resistance bacterial isolatesen_US
dc.typeArticleen_US

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