Clinical implications of the interaction between HPV and HIV infections

dc.contributor.authorDreyer, Greta
dc.date.accessioned2017-10-30T12:33:32Z
dc.date.issued2018-02
dc.description.abstractHIV-related immunodeficiency has complex effects on female genital HPV, which include increased risks of infection, multiple types, persistence, reactivation and the risk to develop pre-invasive and invasive disease. Reconstitution of immunity with anti-viral drugs improves cellular immunity, but the risk of HPV-related malignancy remains higher than background incidences and presents at younger ages. Early initiation of antiretroviral therapy (ART) allows improved retention of immune memory through existing antibodies and T-cell clones and improves long-term outcomes. Suggestions of a higher risk to contract HIV if there is existing genital HPV infection are supported and explained by pathophysiological cervical changes, including inflammation. HIV–HPV interactions should influence public health decisions towards prioritising large-scale prepubertal HPV-vaccine roll-out, secondary cervical cancer prevention and early detection programmes for HIV-infected women and early initiation of ART. This chapter will also focus on special considerations for the management of women with co-infection with these two viruses and genital HPV-related diseases.en_ZA
dc.description.departmentObstetrics and Gynaecologyen_ZA
dc.description.embargo2019-02-01
dc.description.librarianhj2017en_ZA
dc.description.urihttp://www.elsevier.com/locate/bpobgynen_ZA
dc.identifier.citationDreyer, G. 2018, 'Clinical implications of the interaction between HPV and HIV infections', Best Practice and Research: Clinical Obstetrics and Gynaecology, vol. 47, pp. 95-106.en_ZA
dc.identifier.issn1521-6934 (print)
dc.identifier.issn1532-1932 (online)
dc.identifier.other10.1016/j.bpobgyn.2017.08.011
dc.identifier.urihttp://hdl.handle.net/2263/62974
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2017 Published by Elsevier Ltd. Notice : this is the author’s version of a work that was accepted for publication in Best Practice and Research Clinical Obstetrics and Gynaecology . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Best Practice and Research Clinical Obstetrics and Gynaecology, vol. 47, pp. 95-106. 2018. doi : 10.1016/j.bpobgyn.2017.08.011.en_ZA
dc.subjectAntiretroviral therapy (ART)en_ZA
dc.subjectCervical HPVen_ZA
dc.subjectCervical pre-canceren_ZA
dc.subjectCervical canceren_ZA
dc.subjectImmune deficiencyen_ZA
dc.subjectHuman papillomavirus (HPV)en_ZA
dc.subjectHuman immunodeficiency virus (HIV)en_ZA
dc.titleClinical implications of the interaction between HPV and HIV infectionsen_ZA
dc.typePostprint Articleen_ZA

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