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Incidence of cardiometabolic diseases in a Lesotho HIV cohort : evidence for policy decision-making

dc.contributor.authorSebilo, Motlalepula
dc.contributor.authorLedibane, Neo R.T.
dc.contributor.authorTakuva, Simbarashe G.
dc.date.accessioned2022-10-11T12:45:41Z
dc.date.available2022-10-11T12:45:41Z
dc.date.issued2021-06-28
dc.description.abstractBACKGROUND: Antiretroviral treatment (ART) has been associated with the development of certain cardiometabolic diseases (CMDs). The burden of CMDs amongst ART-experienced patients in sub-Saharan Africa was unknown. OBJECTIVE: We quantified the burden of CMDs and identified the associated risk factors in a large treatment cohort on ART at a high-volume facility in Lesotho. METHODS: In this retrospective cohort study, we extracted data from the daily dispensing electronic system and routine clinical records of 785 adults on ART between 2011 and 2015 in Maseru, Lesotho. CMD was defined as a diagnosis of hypertension, diabetes mellitus or dyslipidaemia (singly or collectively). Descriptive statistics were used to describe the disease burden; Kaplan–Meier curves and cause-specific Cox proportional hazards models were fitted to examine the impact of the ART regimen and identify the risk factors associated with the occurrence of CMD. RESULTS: Of the 785 participants, 473 (60%) were women. The median age of the group was 42 years, interquartile range (IQR), 36–51 years. The overall incidence of CMD was 5.6 (95% confidence interval [CI] = 4.4–7.1) per 100 person-months of follow-up. The median time to onset of CMD was 16.6 months (IQR = 7.4–23.4). ART was not associated with the occurrence of CMD (cause-specific hazard ratio [CHR] = 1.55; 95% CI = 0.14–16.85; P = 0.72). Higher body mass index (BMI) was associated with the occurrence of diabetes mellitus (CHR = 1.19; 95% CI = 1.14–1.38; P = 0.026). CONLCUSION: The incidence of CMD in this relatively young patient population is low yet noteworthy. We recommend that patients living with HIV and AIDS should be routinely screened for CMD. Higher BMI is generally associated with the occurrence of CMD.en_US
dc.description.departmentSchool of Health Systems and Public Health (SHSPH)en_US
dc.description.librariandm2022en_US
dc.description.urihttp://www.sajhivmed.org.za/index.php/hivmeden_US
dc.identifier.citationSebilo, M., Ledibane, N.R.T. & Takuva, S. Incidence of cardiometabolic diseases in a Lesotho HIV cohort: Evidence for policy decision-making. Southern African Journal of HIV Medicine 2021;22(1), a1246. https://doi.org/10.4102/ sajhivmed.v22i1.1246en_US
dc.identifier.issn2078-6751 (online)
dc.identifier.issn1608-9693 (print)
dc.identifier.other10.4102/ sajhivmed.v22i1.1246
dc.identifier.urihttps://repository.up.ac.za/handle/2263/87633
dc.language.isoenen_US
dc.publisherAOSISen_US
dc.rights© 2021. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.en_US
dc.subjectAntiretroviral treatmenten_US
dc.subjectIncidence rateen_US
dc.subjectLesothoen_US
dc.subjectAcquired immune deficiency syndrome (AIDS)en_US
dc.subjectHuman immunodeficiency virus (HIV)en_US
dc.subjectAntiretroviral (ARV)en_US
dc.subjectAntiretroviral therapy (ART)en_US
dc.subjectCardiometabolic disease (CMD)en_US
dc.titleIncidence of cardiometabolic diseases in a Lesotho HIV cohort : evidence for policy decision-makingen_US
dc.typeArticleen_US

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