Anal plasmablastic lymphoma with complete response to antiretroviral therapy - a case report
| dc.contributor.author | Montwedi, Daniel | |
| dc.contributor.author | Ramabulana, M. | |
| dc.contributor.author | Khan, Nausheen | |
| dc.contributor.email | daniel.montwedi@up.ac.za | |
| dc.date.accessioned | 2025-10-01T06:28:45Z | |
| dc.date.available | 2025-10-01T06:28:45Z | |
| dc.date.issued | 2025-06 | |
| dc.description.abstract | A 40-year-old male, known to be positive with the human immunodeficiency virus (HIV), presented with a large perianal mass and faecal obstruction. His CD4 count was 121 cells/mm3 suggesting advanced HIV disease, and he was started on second-line antiretroviral therapy. Magnetic resonance imaging (MRI) confirmed a large mass involving the anorectal junction. A biopsy of the tumor revealed a plasmablastic lymphoma (PBL). A diverting colostomy was performed for faecal obstruction. While awaiting chemotherapy treatment, the tumour rapidly decreased in size with complete clinical resolution. PBL is rare and has a dismal prognosis. Spontaneous regression of PBL has been reported but regression on second-line antiretroval therapy has not been previously described. | |
| dc.description.department | Surgery | |
| dc.description.department | Radiology | |
| dc.description.librarian | hj2025 | |
| dc.description.sdg | SDG-03: Good health and well-being | |
| dc.description.uri | https://medpharm.co.za/about-our-journals/sajs/ | |
| dc.identifier.citation | Montwedi, D., Ramabulana, M. & Khan, N. 2025, 'Anal plasmablastic lymphoma with complete response to antiretroviral therapy-a case report', South African Journal of Surgery, vol. 63, no. 2, pp. 98-100, doi : 10.36303/SAJS.00917. | |
| dc.identifier.issn | 0038-2361 (print) | |
| dc.identifier.issn | 2078-5151 (online) | |
| dc.identifier.other | 10.36303/SAJS.00917 | |
| dc.identifier.uri | http://hdl.handle.net/2263/104547 | |
| dc.language.iso | en | |
| dc.publisher | Medpharm Publications | |
| dc.rights | © 2025 The Author(s). Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial Works 4.0 South Africa License (CC BY NC) http://creativecommons.org/licenses/by-nc-nd/4.0. | |
| dc.subject | Case report | |
| dc.subject | Human immunodeficiency virus (HIV) | |
| dc.subject | Magnetic resonance imaging (MRI) | |
| dc.subject | Plasmablastic lymphoma (PBL) | |
| dc.subject | Lymphoma | |
| dc.subject | Anal tumour | |
| dc.subject | Ammon regression | |
| dc.title | Anal plasmablastic lymphoma with complete response to antiretroviral therapy - a case report | |
| dc.type | Article |