Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica

dc.contributor.authorMelong, Raduis
dc.contributor.authorMaffo, Timoleon
dc.contributor.authorKapche, Deccaux G.W.F.
dc.contributor.authorNgadjui, Bonaventure T.
dc.contributor.upauthorDzoyem, Jean Paul
dc.contributor.upauthorMcGaw, Lyndy Joy
dc.contributor.upauthorEloff, Jacobus Nicolaas
dc.date.accessioned2017-07-31T09:33:07Z
dc.date.available2017-07-31T09:33:07Z
dc.date.issued2017-03
dc.description.abstractFour compounds including beauvericin, parahydroxybenzaldehyde, indole-3-carboxylic acid and quinizarin were isolated from endophytic fungus Epicoccum nigrum and their cytotoxicity, antibacterial and antioxidant activity were evaluated. Beauvericin had remarkable activity against two Gram-negative strains (Bacillus cereus and Salmonella typhimurium) with respective MIC values of 3.12 and 6.25 g/ml. All the compounds had weak cytotoxic effect on both normal and tumor cells. LC50values ranged from 40.42 to 86.56 g/ml, 31.87 to 86.57 g/ml and 21.59 to 67.27 g/ml on Vero cells, THP-1 and RAW 264.7 respectively. The present study showed that these compounds could be developed for the formulation of antioxidant-rich therapeutic diets and as a therapeutic agent against bacterial infections.en_ZA
dc.description.departmentParaclinical Sciencesen_ZA
dc.description.librarianam2017en_ZA
dc.description.sponsorshipThe National Research Foundation and Medical Research Council.en_ZA
dc.description.urihttp://www.elsevier.com/locate/bjpen_ZA
dc.identifier.citationDzoyem J.P., Melong R., Tsamo A.T., Maffo T., Kapche D.G.W.F., Ngadjui B.T., McGaw L.J. & Eloff J.N. 2017, 'Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica', Revista Brasileira de Farmacognosia/Brazilian Journal of Pharmacognosy, vol. 27, pp. 251-253.en_ZA
dc.identifier.issn0102-695X
dc.identifier.other10.1016/j.bjp.2016.08.011
dc.identifier.urihttp://hdl.handle.net/2263/61529
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2016 Sociedade Brasileira de Farmacognosia. This is an openaccess article under the CC BY-NC-ND license.en_ZA
dc.subjectAntimicrobialen_ZA
dc.subjectFree radical scavengingen_ZA
dc.subjectCytotoxicityen_ZA
dc.subjectEndophytic fungien_ZA
dc.subjectEpicoccum nigrumen_ZA
dc.titleCytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinicaen_ZA
dc.typeArticleen_ZA

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