Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica
dc.contributor.author | Melong, Raduis | |
dc.contributor.author | Maffo, Timoleon | |
dc.contributor.author | Kapche, Deccaux G.W.F. | |
dc.contributor.author | Ngadjui, Bonaventure T. | |
dc.contributor.upauthor | Dzoyem, Jean Paul | |
dc.contributor.upauthor | McGaw, Lyndy Joy | |
dc.contributor.upauthor | Eloff, Jacobus Nicolaas | |
dc.date.accessioned | 2017-07-31T09:33:07Z | |
dc.date.available | 2017-07-31T09:33:07Z | |
dc.date.issued | 2017-03 | |
dc.description.abstract | Four compounds including beauvericin, parahydroxybenzaldehyde, indole-3-carboxylic acid and quinizarin were isolated from endophytic fungus Epicoccum nigrum and their cytotoxicity, antibacterial and antioxidant activity were evaluated. Beauvericin had remarkable activity against two Gram-negative strains (Bacillus cereus and Salmonella typhimurium) with respective MIC values of 3.12 and 6.25 g/ml. All the compounds had weak cytotoxic effect on both normal and tumor cells. LC50values ranged from 40.42 to 86.56 g/ml, 31.87 to 86.57 g/ml and 21.59 to 67.27 g/ml on Vero cells, THP-1 and RAW 264.7 respectively. The present study showed that these compounds could be developed for the formulation of antioxidant-rich therapeutic diets and as a therapeutic agent against bacterial infections. | en_ZA |
dc.description.department | Paraclinical Sciences | en_ZA |
dc.description.librarian | am2017 | en_ZA |
dc.description.sponsorship | The National Research Foundation and Medical Research Council. | en_ZA |
dc.description.uri | http://www.elsevier.com/locate/bjp | en_ZA |
dc.identifier.citation | Dzoyem J.P., Melong R., Tsamo A.T., Maffo T., Kapche D.G.W.F., Ngadjui B.T., McGaw L.J. & Eloff J.N. 2017, 'Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica', Revista Brasileira de Farmacognosia/Brazilian Journal of Pharmacognosy, vol. 27, pp. 251-253. | en_ZA |
dc.identifier.issn | 0102-695X | |
dc.identifier.other | 10.1016/j.bjp.2016.08.011 | |
dc.identifier.uri | http://hdl.handle.net/2263/61529 | |
dc.language.iso | en | en_ZA |
dc.publisher | Elsevier | en_ZA |
dc.rights | © 2016 Sociedade Brasileira de Farmacognosia. This is an openaccess article under the CC BY-NC-ND license. | en_ZA |
dc.subject | Antimicrobial | en_ZA |
dc.subject | Free radical scavenging | en_ZA |
dc.subject | Cytotoxicity | en_ZA |
dc.subject | Endophytic fungi | en_ZA |
dc.subject | Epicoccum nigrum | en_ZA |
dc.title | Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica | en_ZA |
dc.type | Article | en_ZA |