The Synthesis and analysis of methaqualone and some positional structural isomers thereof
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University of Pretoria
Abstract
An extensive review of the reported synthesis of methaqualone (2-methyl-3-ο-tolyl-4(3H)-quinazolinone) and some positional and structural isomers of methaqualone is given. A detailed summary of the synthetic routes reviewed is given as an appendix. Methaqualone, four previously reported, and seven until hereto unreported isomers of methaqualone were prepared using a modified, known synthetic route for quinazolinones. The modified route allowed for the rapid laboratory scale preparation of the desired quinazolinones in high yields. Melting points are given. The prepared compounds were characterized using various organic analytical techniques. NMR and IR was found to be the most specific single techniques for the effectively and unequivocally differentiation between the studied compounds. The most convenient, and equally specific, differentiation was achieved using coupled gas-liquid chromatography. The thin-layer chromatography and liquid chromatography systems evaluated proved of no value in differentiating the thirteen isomers.
Description
Dissertation (MSc Applied Sciences (Chemistry))--University of Pretoria, 2006.
Keywords
Methaqualone synthesis, Methaqualone analysis, UCTD
Sustainable Development Goals
Citation
Van Zyl, EF 2001, The synthesis and analysis of methaqualone and some positional and structural isomers thereof, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/29713 >