Factors associated with mortality in children under five years old hospitalized for severe acute malnutrition in Limpopo province, South Africa, 2014-2018 : a cross-sectional analytic study

dc.contributor.authorGavhi, Fhatuwani
dc.contributor.authorKuonza, Lazarus R.
dc.contributor.authorMusekiwa, Alfred
dc.contributor.authorMotaze, Nkengafac Villyen
dc.date.accessioned2021-04-19T06:20:43Z
dc.date.available2021-04-19T06:20:43Z
dc.date.issued2020-05-08
dc.descriptionS1 File. Ethical approval letter.en_ZA
dc.descriptionS1 Dataset. Manuscript data.en_ZA
dc.description.abstractBACKGROUND : In South Africa, 30.9% of children under five years with Severe Acute Malnutrition (SAM) died in 2018. We aimed to identify factors associated with mortality among children under five years hospitalized with SAM in Limpopo province, South Africa. METHODS : We conducted a cross-sectional study including children under five years admitted with SAM from 2014 to 2018 in public hospitals of Limpopo province. We extracted socio-demographic and clinical data from hospital records. We used logistic regression to identify factors associated with mortality. FINDINGS : We included 956 children, 50.2% (480/956) male and 49.8% (476/956) female. The median age was 13 months (inter quartile range: 9–19 months). The overall SAM mortality over the study period was 25.9% (248/956). The most common complications were diarrhea, 63.8% (610/956), and lower respiratory tract infections (LRTIs), 42.4% (405/956). Factors associated with mortality included herbal medication use (adjusted Odds Ratio (aOR): 2.2, 95% Confidence Interval (CI): 1.4–3.5, p = 0.001), poor appetite (aOR: 2.7, 95% CI: 1.4–5.2, p = 0.003), Mid-upper circumference (MUAC) <11.5 cm (aOR: 3.0, 95% CI: 1.9–4.7, p<0.001), lower respiratory tract infections (LRTIs) (aOR: 1.6, 95% CI: 1.2–2.0, p<0.001), anemia (aOR: 2.5, 95% CI: 1.1–5.3, p = 0.021), hypoglycemia (aOR: 12.4, 95% CI: 7.1–21.8, p<0.001) and human immunodeficiency virus (HIV) infection (aOR: 2.3, 95% CI: 1.6–3.3, p<0.001). INTERPRETATION : Herbal medication use, poor appetite, LRTIs, anemia, hypoglycemia, and HIV infection were associated with mortality among children with SAM. These factors should guide management of children with SAM.en_ZA
dc.description.departmentSchool of Health Systems and Public Health (SHSPH)en_ZA
dc.description.librarianam2021en_ZA
dc.description.urihttp://www.plosone.orgen_ZA
dc.identifier.citationGavhi, F., Kuonza, L., Musekiwa, A., Motaze, N.V. (2020) Factors associated with mortality in children under five years old hospitalized for Severe Acute Malnutrition in Limpopo province, South Africa, 2014-2018: A cross-sectional analytic study. PLoS ONE 15(5): e0232838. https://DOI.org/10.1371/journal.pone.0232838.en_ZA
dc.identifier.issn1932-6203 (online)
dc.identifier.other10.1371/journal.pone.0232838
dc.identifier.urihttp://hdl.handle.net/2263/79485
dc.language.isoenen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.rights© 2020 Gavhi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.en_ZA
dc.subjectMortalityen_ZA
dc.subjectChildrenen_ZA
dc.subjectLimpopo Province, South Africaen_ZA
dc.subjectSevere acute malnutrition (SAM)en_ZA
dc.titleFactors associated with mortality in children under five years old hospitalized for severe acute malnutrition in Limpopo province, South Africa, 2014-2018 : a cross-sectional analytic studyen_ZA
dc.typeArticleen_ZA

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