Isolation, biosynthesis and chemical modifications of rubterolones A-F : rare tropolone alkaloids from Actinomadura sp. 5-2
dc.contributor.author | Guo, Huijuan | |
dc.contributor.author | Benndorf, Rene | |
dc.contributor.author | Leichnitz, Daniel | |
dc.contributor.author | Klassen, Jonathan L. | |
dc.contributor.author | Vollmers, John | |
dc.contributor.author | Goerls, Helmar | |
dc.contributor.author | Steinacker, Matthias | |
dc.contributor.author | Weigel, Christiane | |
dc.contributor.author | Dahse, Hans-Martin | |
dc.contributor.author | Kaster, Anne-Kristin | |
dc.contributor.author | Poulsen, Michael | |
dc.contributor.author | Beemelmanns, Christine | |
dc.contributor.upauthor | De Beer, Z. Wilhelm | |
dc.date.accessioned | 2017-08-14T08:41:25Z | |
dc.date.issued | 2017-07 | |
dc.description.abstract | The discovery of six new, highly substituted tropolone alkaloids, rubterolones A–F, from Actinomadura sp. 5-2, isolated from the gut of the fungus-growing termite Macrotermes natalensis is reported. Rubterolones were identified by using fungus-bacteria challenge assays and a HRMS-based dereplication strategy, and characterised by NMR and HRMS analyses and by X-ray crystallography. Feeding experiments and subsequent chemical derivatisation led to a first library of rubterolone derivatives (A–L). Genome sequencing and comparative analyses revealed their putative biosynthetic pathway, which was supported by feeding experiments. This study highlights how gut microbes can present a prolific source of secondary metabolites. | en_ZA |
dc.description.department | Forestry and Agricultural Biotechnology Institute (FABI) | en_ZA |
dc.description.department | Microbiology and Plant Pathology | en_ZA |
dc.description.embargo | 2018-07-12 | |
dc.description.librarian | hj2017 | en_ZA |
dc.description.sponsorship | The Daimler Benz foundation to C.B., the Villum Kann Rasmussen Foundation for a Young Investigator Fellowship (VKR10101) to M.P. R.B., the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS) and School for Microbial Communication (JSMC, DFG). | en_ZA |
dc.description.uri | http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3765 | en_ZA |
dc.identifier.citation | Guo, H.J., Benndorf, R., Leichnitz, D., Klassen, J.L., Vollmers, J., Gorls, H., Steinacker, M., Weigel, C., Dahse, H.M., Kaster, A.K., De Beer, Z.W., Poulsen, M. & Beemelmanns, C. 2017, 'Isolation, biosynthesis and chemical modifications of rubterolones A-F : rare tropolone alkaloids from Actinomadura sp. 5-2', Chemistry : A European Journal, vol. 23, no. 39, 9338-9345. | en_ZA |
dc.identifier.issn | 1521-3765 (online) | |
dc.identifier.issn | 0947-6539 (print) | |
dc.identifier.other | 10.1002/chem.201701005 | |
dc.identifier.uri | http://hdl.handle.net/2263/61635 | |
dc.language.iso | en | en_ZA |
dc.publisher | Wiley | en_ZA |
dc.rights | © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the pre-peer reviewed version of the following article : 'Isolation, biosynthesis and chemical modifications of rubterolones A-F : rare tropolone alkaloids from Actinomadura sp. 5-2', Chemistry : A European Journal, vol. 23, no. 39, 9338-9345., 2017, doi : 10.1002/chem.201701005. The definite version is available at : http://onlinelibrary.wiley.comjournal/10.1002/(ISSN)1521-3765. | en_ZA |
dc.subject | Biosynthesis | en_ZA |
dc.subject | Polyketides | en_ZA |
dc.subject | Natural products | en_ZA |
dc.subject | Drug discovery | en_ZA |
dc.subject | Chemical probes | en_ZA |
dc.title | Isolation, biosynthesis and chemical modifications of rubterolones A-F : rare tropolone alkaloids from Actinomadura sp. 5-2 | en_ZA |
dc.type | Postprint Article | en_ZA |
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