Herbal remedies affecting coagulation : a review

dc.contributor.authorCordier, Werner
dc.contributor.authorSteenkamp, Vanessa
dc.contributor.emailvanessa.steenkamp@up.ac.zaen_US
dc.date.accessioned2012-08-07T14:23:42Z
dc.date.available2013-04-30T00:20:03Z
dc.date.issued2012-04
dc.description.abstractCONTEXT: Herbal remedies are used to treat a large variety of diseases, including blood-related disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, this is mainly by disruption of the coagulation cascade. OBJECTIVE: The compiling of plants investigated for effects on the coagulation cascade. METHODS: Information was withdrawn from Google Scholar and the journal databases Scopus and PubMed. RESULTS: Sixty-five herbal remedies ware identified with antiplatelet, anticoagulant or coagulating ability. Bioactive compounds included polyphenols, taxanes, coumarins, saponins, fucoidans, and polysaccharides. CONCLUSION: Although research has been conducted on the effect of herbal remedies on coagulation, most information relies on in vitro assays. Contradictory evidence is present on bleeding risks with herbal uses, though herb-drug interactions pose a threat. As the safety of many herbals has not been proven, nor their effect on blood parameters determined, the use of herbal preparations before undergoing any surgical procedure should rather be ceased.en_US
dc.description.urihttp://www.tandf.co.uk/journals/titles/13880209.aspen_US
dc.identifier.citationCordier, W & Steenkamp, V 2012, 'Herbal remedies affecting coagulation : a review', Pharmaceutical Biology, vol. 50, no. 4, pp. 443-452.en_US
dc.identifier.issn1388-0209 (print)
dc.identifier.issn1744-5116 (online)
dc.identifier.other10.3109/13880209.2011.611145
dc.identifier.urihttp://hdl.handle.net/2263/19565
dc.language.isoenen_US
dc.publisherRoutledgeen_US
dc.rights© Taylor & Francis. This is an electronic version of an article published in Pharmaceutical Biology, vol. 50, no. 4, pp. 443-452, 2012. Pharmaceutical Biology is available online at: http://www.tandf.co.uk/journals/titles/13880209.aspen_US
dc.subjectAntiplateleten_US
dc.subjectAntithromboticen_US
dc.subjectAnticoagulanten_US
dc.subjectExtracten_US
dc.subjectPerioperative bleedingen_US
dc.subject.lcshHerbs -- Therapeutic useen
dc.subject.lcshBlood coagulation disordersen
dc.subject.lcshPharmacokineticsen
dc.titleHerbal remedies affecting coagulation : a reviewen_US
dc.typePostprint Articleen_US

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