Antimicrobial activity of medicinal plants against oral microorganisms

dc.contributor.authorMore, Garland Kgosi
dc.contributor.authorTshikalange, Thilivhali Emmanuel
dc.contributor.authorLall, Namrita
dc.contributor.authorBotha, Francien Susanna
dc.contributor.authorMeyer, Jacobus Johannes Marion
dc.date.accessioned2009-05-28T06:37:22Z
dc.date.available2009-05-28T06:37:22Z
dc.date.issued2008-10
dc.description.abstractEthanol extracts of eight plant species used traditionally in South Africa for the treatment of oral diseases were investigated for in vitro antimicrobial activity against oral pathogens namely Actinobacillus actinomycetemcomitans, Actinomyces naeslundii, Actinomyces israelii, Candida albicans, Porphyromonus gingivalis, Privotella intermedia and Streptococcus mutans using the disk diffusion method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ethanol extracts were determined against these microorganisms using micro dilution. The cytotoxicity and therapeutic index (TI) of selected active extracts were also determined. Out of eight plants, six (Annona senegalensis, Englerophytum magalismontanum, Dicerocarym senecioides, Euclea divinorum, Euclea natalensis, Solanum panduriforme and Parinari curatellifolia) exhibited MIC values ranging from 25.0 mg/ml to 0.8 mg/ml. Gram negative bacteria were found to be more resistant to the plant extracts than Gram positive bacteria, except for Euclea natalensis which inhibited all three Gram negative bacteria tested in this study. All plant extracts showed moderate cytotoxicity on the Vero cell line. The fifty percent inhibitory concentration (IC50) of all plants tested range from 92.3 to 285.1μg/ml.en_US
dc.description.sponsorshipNational Research Foundation and Division of Stomatological Research, Department of Community Dentistry.en_US
dc.identifier.citationMore, G, Tshikalange, TE, Lall, N, Botha, F & Meyer, JJM 2008, 'Antimicrobial activity of medicinal plants against oral microorganisms', Journal of Ethnopharmacology, vol. 119, no. 3, pp. 473-477. [http://www.elsevier.com/locate/jethpharm]en_US
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/2263/10219
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsElsevieren_US
dc.subjectAntimicrobial activitiesen_US
dc.subjectMedicinal plantsen_US
dc.subjectOral microorganismsen_US
dc.subjectPeriodontal diseaseen_US
dc.subject.lcshMouth -- Diseases -- South Africa
dc.subject.lcshMateria medica, Vegetable -- South Africa
dc.subject.lcshAnti-infective agents -- South Africa
dc.titleAntimicrobial activity of medicinal plants against oral microorganismsen_US
dc.typePostprint Articleen_US

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