Zoonotic tuberculosis—a call for an open One Health debate

dc.contributor.authorZumla, Alimuddin
dc.contributor.authorYeboah-Manu, Dorothy
dc.contributor.authorMichel, Anita Luise
dc.contributor.authorAzhar, Esam I.
dc.contributor.authorTorrelles, Jordi B.
dc.contributor.authorCadmus, Simeon I.
dc.contributor.authorKendall, Sharon L.
dc.contributor.authorChakaya, Jeremiah M.
dc.contributor.authorMarais, Ben
dc.contributor.authorKock, Richard
dc.date.accessioned2021-01-14T09:41:02Z
dc.date.issued2020-06
dc.description.abstractTuberculosis is caused by bacteria of the Mycobacterium tuberculosis complex (MTBC) and affects both human and animal populations. Animal-adapted MTBC threatens the wellbeing of humans, animals, and their livelihoods. The 2019 WHO annual tuberculosis report estimated that there were 143 000 new human cases of zoonotic tuberculosis with 12 300 deaths caused by Mycobacterium bovis globally in 2018. Prevalence estimates of zoonotic tuberculosis are inaccurate, however, because routine laboratory tests cannot differentiate between infections caused by the human-adapted and animal-adapted species of MTBC, including newer members such as Mycobacterium orygis. Thus, the true effect of zoonotic tuberculosis on the human tuberculosis epidemic remains unclear. Accurate disease differentiation is also important given that M bovis is universally resistant to pyrazinamide, a key first-line tuberculosis drug.en_ZA
dc.description.departmentVeterinary Tropical Diseasesen_ZA
dc.description.embargo2021-06-01
dc.description.librarianhj2020en_ZA
dc.description.urihttp://www.thelancet.com/infectionen_ZA
dc.identifier.citationZumla, A., Yeboah-Manu, D., Michel, A.L. et al. 2020, 'Zoonotic tuberculosis—a call for an open One Health debate', The Lancet Infectious Diseases, vol. 20, no. 6, pp. 642-644.en_ZA
dc.identifier.issn1473-3099 (print)
dc.identifier.issn1474-4457 (online)
dc.identifier.other10.1016/S1473-3099(20)30166-3
dc.identifier.urihttp://hdl.handle.net/2263/78019
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2020 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Lancet Infectious Diseases. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Lancet Infectious Diseases, vol. 20, no. 6, pp. 642-644, 2020. doi : 10.1016/S1473-3099(20)30166-3.en_ZA
dc.subjectZoonotic tuberculosisen_ZA
dc.subjectMycobacterium tuberculosis complex (MTBC)en_ZA
dc.titleZoonotic tuberculosis—a call for an open One Health debateen_ZA
dc.typePostprint Articleen_ZA

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