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Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population

dc.contributor.authorPetersen, Desiree C.
dc.contributor.authorGlashoff, Richard H.
dc.contributor.authorSherestha, Sadeep
dc.contributor.authorBergeron, Julie
dc.contributor.authorLaten, Anette
dc.contributor.authorGold, Bert
dc.contributor.authorJanse van Rensburg, Estrelita
dc.contributor.authorDean, Michael
dc.contributor.authorHayes, Vanessa M.
dc.date.accessioned2007-07-27T05:59:39Z
dc.date.available2007-07-27T05:59:39Z
dc.date.issued2005-12-15
dc.description.abstractCXC chemokine ligand 12 (CXCL12), or stromal cell–derived factor 1 (SDF1), is the only known natural ligand for the HIV-1 coreceptor, CXC chemokine receptor 4 (CXCR4). A single nucleotide polymorphism (SNP) in the CXCL12 gene (SDF1-3'A) has been associated with disease progression to AIDS in some studies, but not others. Mutations in the CXCR4 gene are generally rare and have not been implicated in HIV-1/AIDS pathogenesis. This study analyzed the SDF1-3'A SNP and performed mutation screening for polymorphic markers in the CXCR4 gene to determine the presence or absence of significant associations with susceptibility to HIV-1 infection. The study consisted of 257 HIV-1–seropositive patients and 113 HIV-1–seronegative controls representing a sub-Saharan African population belonging to the Xhosa ethnic group of South Africa. The SDF1-3'A SNP was associated with an increased risk for HIV-1 infection (P = 0.0319) whereas no significant association was observed between the occurrence of the SDF1-3'A SNP and increased or decreased plasma levels of CXCL12. Comprehensive mutation analysis of the CXCR4 gene confirmed a high degree of genetic conservation within the coding region of this ancient population.en
dc.description.sponsorshipThe authors thank Lehana Breytenbach for sample collection and maintenance of the HIV database; Heather Money for the coordination of blood specimens from the Western Province Blood Transfusion Service; all clinicians and nursing staff at the HIV clinics and blood transfusion services of the Western Cape; and the study participants.en
dc.format.extent11637 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationPetersen, DC, Glashoff, RH, Shrestha, S, Bergeron, J, Laten, A, Gold, B, Janse van Rensburg, E, Dean, M & Hayes, VM 2005,'Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and conservation of CXCR4 in an African population', Journal of Acquired Immune Deficiency Syndrome, vol. 40, no. 5, pp. 521-526.[http://www.lww.com/product/?1525-4135]en
dc.identifier.issn1525-4135
dc.identifier.urihttp://hdl.handle.net/2263/3169
dc.language.isoenen
dc.publisherLippincott Williams and Wilkinsen
dc.rightsLippincott Williams and Wilkins. The publisher prohibits open access to the full text of this articleen
dc.subjectCXC chemokine ligand 12 (CXCL12)en
dc.subjectCXC chemokineen
dc.subjectSDF1-3'A single-nucleotide polymorphismen
dc.subjectHIV-1 infection risken
dc.subjectAfrican populationen
dc.subject.lcshHIV infections -- Research
dc.subject.lcshAIDS (Disease) -- Sub-Saharan Africa
dc.titleRisk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African populationen
dc.typeArticleen

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