Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population
dc.contributor.author | Petersen, Desiree C. | |
dc.contributor.author | Glashoff, Richard H. | |
dc.contributor.author | Sherestha, Sadeep | |
dc.contributor.author | Bergeron, Julie | |
dc.contributor.author | Laten, Anette | |
dc.contributor.author | Gold, Bert | |
dc.contributor.author | Janse van Rensburg, Estrelita | |
dc.contributor.author | Dean, Michael | |
dc.contributor.author | Hayes, Vanessa M. | |
dc.date.accessioned | 2007-07-27T05:59:39Z | |
dc.date.available | 2007-07-27T05:59:39Z | |
dc.date.issued | 2005-12-15 | |
dc.description.abstract | CXC chemokine ligand 12 (CXCL12), or stromal cell–derived factor 1 (SDF1), is the only known natural ligand for the HIV-1 coreceptor, CXC chemokine receptor 4 (CXCR4). A single nucleotide polymorphism (SNP) in the CXCL12 gene (SDF1-3'A) has been associated with disease progression to AIDS in some studies, but not others. Mutations in the CXCR4 gene are generally rare and have not been implicated in HIV-1/AIDS pathogenesis. This study analyzed the SDF1-3'A SNP and performed mutation screening for polymorphic markers in the CXCR4 gene to determine the presence or absence of significant associations with susceptibility to HIV-1 infection. The study consisted of 257 HIV-1–seropositive patients and 113 HIV-1–seronegative controls representing a sub-Saharan African population belonging to the Xhosa ethnic group of South Africa. The SDF1-3'A SNP was associated with an increased risk for HIV-1 infection (P = 0.0319) whereas no significant association was observed between the occurrence of the SDF1-3'A SNP and increased or decreased plasma levels of CXCL12. Comprehensive mutation analysis of the CXCR4 gene confirmed a high degree of genetic conservation within the coding region of this ancient population. | en |
dc.description.sponsorship | The authors thank Lehana Breytenbach for sample collection and maintenance of the HIV database; Heather Money for the coordination of blood specimens from the Western Province Blood Transfusion Service; all clinicians and nursing staff at the HIV clinics and blood transfusion services of the Western Cape; and the study participants. | en |
dc.format.extent | 11637 bytes | |
dc.format.mimetype | application/pdf | |
dc.identifier.citation | Petersen, DC, Glashoff, RH, Shrestha, S, Bergeron, J, Laten, A, Gold, B, Janse van Rensburg, E, Dean, M & Hayes, VM 2005,'Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and conservation of CXCR4 in an African population', Journal of Acquired Immune Deficiency Syndrome, vol. 40, no. 5, pp. 521-526.[http://www.lww.com/product/?1525-4135] | en |
dc.identifier.issn | 1525-4135 | |
dc.identifier.uri | http://hdl.handle.net/2263/3169 | |
dc.language.iso | en | en |
dc.publisher | Lippincott Williams and Wilkins | en |
dc.rights | Lippincott Williams and Wilkins. The publisher prohibits open access to the full text of this article | en |
dc.subject | CXC chemokine ligand 12 (CXCL12) | en |
dc.subject | CXC chemokine | en |
dc.subject | SDF1-3'A single-nucleotide polymorphism | en |
dc.subject | HIV-1 infection risk | en |
dc.subject | African population | en |
dc.subject.lcsh | HIV infections -- Research | |
dc.subject.lcsh | AIDS (Disease) -- Sub-Saharan Africa | |
dc.title | Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population | en |
dc.type | Article | en |