Imaging bacteria with radiolabelled probes : is it feasible?

dc.contributor.authorSignore, Alberto
dc.contributor.authorArtiko, Vera
dc.contributor.authorConserva, Martina
dc.contributor.authorFerro-Flores, Guillermina
dc.contributor.authorWelling, Mick M.
dc.contributor.authorJain, Sanjay K.
dc.contributor.authorHess, Soren
dc.contributor.authorSathekge, Mike Machaba
dc.contributor.emailmike.sathekge@up.ac.zaen_ZA
dc.date.accessioned2020-11-04T08:26:51Z
dc.date.available2020-11-04T08:26:51Z
dc.date.issued2020-07-25
dc.descriptionConceptualization of this paper was made by A.S. and M.S.; data were obtained and analyzed by G.F.-F., M.M.W. and S.K.J. and S.H.; draft preparation by M.C. and A.S.; review and editing by A.S., V.A., M.C., G.F.-F., M.M.W., S.K.J., S.H. and M.S.en_ZA
dc.description.abstractBacterial infections are the main cause of patient morbidity and mortality worldwide. Diagnosis can be di cult and delayed as well as the identification of the etiological pathogen, necessary for a tailored antibiotic therapy. Several non-invasive diagnostic procedures are available, all with pros and cons. Molecular nuclear medicine has highly contributed in this field by proposing several di erent radiopharmaceuticals (antimicrobial peptides, leukocytes, cytokines, antibiotics, sugars, etc.) but none proved to be highly specific for bacteria, although many agents in development look promising. Indeed, factors including the number and strain of bacteria, the infection site, and the host condition, may a ect the specificity of the tested radiopharmaceuticals. At the Third European Congress on Infection/Inflammation Imaging, a round table discussion was dedicated to debate the pros and cons of di erent radiopharmaceuticals for imaging bacteria with the final goal to find a consensus on the most relevant research steps that should be fulfilled when testing a new probe, based on experience and cumulative published evidence.en_ZA
dc.description.departmentNuclear Medicineen_ZA
dc.description.librarianam2020en_ZA
dc.description.urihttp://www.mdpi.com/journal/jcmen_ZA
dc.identifier.citationSignore, A., Artiko, V., Conserva, M. et al. 2020, 'Imaging bacteria with radiolabelled probes : is it feasible?', Journal of Clinical Medicine, vol. 9, art. 2372, pp. 1-10.en_ZA
dc.identifier.issn2077-0383 (print)
dc.identifier.other10.3390/jcm9082372
dc.identifier.urihttp://hdl.handle.net/2263/76698
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights© 2020 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_ZA
dc.subjectInfectionen_ZA
dc.subjectBacteriaen_ZA
dc.subjectRadiopharmaceuticalen_ZA
dc.subjectMolecular imagingen_ZA
dc.subjectNuclear medicineen_ZA
dc.titleImaging bacteria with radiolabelled probes : is it feasible?en_ZA
dc.typeArticleen_ZA

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