A systematic review of DNA methylation and preterm birth in African American women

dc.contributor.authorDe Mendoza, Veronica Barcelona
dc.contributor.authorWright, Michelle L.
dc.contributor.authorAgaba, Comfort
dc.contributor.authorPrescott, Laura
dc.contributor.authorDesir, Alexandra
dc.contributor.authorCrusto, Cindy A.
dc.contributor.authorSun, Yan V.
dc.contributor.authorTaylor, Jacquelyn Y.
dc.date.accessioned2017-12-01T10:11:52Z
dc.date.available2017-12-01T10:11:52Z
dc.date.issued2017-05
dc.description.abstractBACKGROUND : The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. METHODS : The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women. RESULTS : Studies (N = 10) were limited by small sample size, cross-sectional study designs, inconsistent methodologies for epigenomic analysis, and evaluation of different tissue types across studies. African Americans comprised less than half of the sample in 50% of the studies reviewed. Despite these limitations, there is evidence for an association between DNAm patterns and PTB. CONCLUSIONS : Future research on DNAm patterns and PTB should use longitudinal study designs, repeated DNAm testing, and a clinically relevant definition of PTB and should include large samples of high-risk African American women to better understand the mechanisms for PTB in this population.en_ZA
dc.description.departmentPsychologyen_ZA
dc.description.librarianhj2017en_ZA
dc.description.sponsorshipThe National Institutes of Health and National Institute for Nursing Research (R01NR013520).en_ZA
dc.description.urihttp://journals.sagepub.com/home/brnen_ZA
dc.identifier.citationDe Mendoza, V.B., Wright, M.L., Agaba, C. ... et al. 2017, 'A systematic review of DNA methylation and preterm birth in African American women', Biological Research for Nursing, vol. 19. no. 3, pp. 308-317.en_ZA
dc.identifier.issn1099-8004 (priint)
dc.identifier.issn1552-4175 (online)
dc.identifier.other10.1177/1099800416669049
dc.identifier.urihttp://hdl.handle.net/2263/63412
dc.language.isoenen_ZA
dc.publisherSageen_ZA
dc.rights© The Author(s) 2017en_ZA
dc.subjectPreterm birth (PTB)en_ZA
dc.subjectDNA methylation (DNAm)en_ZA
dc.subjectAfrican Americansen_ZA
dc.subjectGestational ageen_ZA
dc.subjectRaceen_ZA
dc.subjectPregnancyen_ZA
dc.titleA systematic review of DNA methylation and preterm birth in African American womenen_ZA
dc.typePostprint Articleen_ZA

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