A comparison of the leaf gel extracts of Aloe ferox and Aloe vera in the topical treatment of atopic dermatitis in Balb/c mice

dc.contributor.authorFinberg, Marike Johanna
dc.contributor.authorMuntingh, George L.
dc.contributor.authorJansen van Rensburg, Connie E.
dc.contributor.emailconnie.medlen@up.ac.zaen_ZA
dc.date.accessioned2015-11-20T10:06:55Z
dc.date.issued2015-12
dc.description.abstractAloe vera gel is widely used in the treatment of an array of disturbances, especially skin disorders. The wound-healing effects have been attributed to its moisturizing and anti-inflammatory effects as well as its beneficial effect on the maturation of collagen. The aim of the present study is to compare the effects of topically applied extracts of Aloe ferox with that of Aloe vera on the symptoms as well as IgE levels of a mouse model of atopic dermatitis (AD). Mice were sensitized and challenged with 2,4-dinitrochlorobenzene and treated afterwards for 10 consecutive days with the gels of either A. ferox or A. vera applied topically to the affected areas. A placebo gel was used for the control mice. Blood was collected at the beginning and end of the treatment period to measure serum IgE levels. Although the gels of both the Aloe species inhibited the cutaneous inflammatory response as well as serum IgE levels in the rats, the extracts of A. ferox were superior to that of A. vera in reducing IgE levels. The gels of A. ferox and A. vera, applied topically, may be a safe and useful alternative to antihistamines and topical corticosteroids, for the treatment of patients suffering from recurring chronic AD.en_ZA
dc.description.embargo2016-12-30
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipGrant from the House of Aloes, Albertinia, SouthAfricaen_ZA
dc.description.urihttp://link.springer.com/journal/10787en_ZA
dc.identifier.citationFinberg, MJ, Muntingh, GL & Van Rensburg, CEJ 2015, 'A comparison of the leaf gel extracts of Aloe ferox and Aloe vera in the topical treatment of atopic dermatitis in Balb/c mice', Inflammopharmacology, vol. 23, no. 6, pp. 337-341.en_ZA
dc.identifier.issn0925-4692 (print)
dc.identifier.issn1568-5608 (online)
dc.identifier.urihttp://hdl.handle.net/2263/50547
dc.language.isoenen_ZA
dc.publisherSpringeren_ZA
dc.rights© Springer Basel 2015. The original publication is available at : http://link.springer.comjournal/10787.en_ZA
dc.subjectAloe feroxen_ZA
dc.subjectAloe veraen_ZA
dc.subjectAtopic dermatitis (AD)en_ZA
dc.subjectLeaf gel extractsen_ZA
dc.subjectSkin disordersen_ZA
dc.subjectTopically applied extractsen_ZA
dc.subjectMiceen_ZA
dc.titleA comparison of the leaf gel extracts of Aloe ferox and Aloe vera in the topical treatment of atopic dermatitis in Balb/c miceen_ZA
dc.typePostprint Articleen_ZA

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