Policing cancer : vitamin D arrests the cell cycle

dc.contributor.authorBhoora, Sachin
dc.contributor.authorPunchoo, Rivak
dc.contributor.emailrivak.punchoo@up.ac.zaen_ZA
dc.date.accessioned2021-05-14T13:38:09Z
dc.date.available2021-05-14T13:38:09Z
dc.date.issued2020-12
dc.description.abstractVitamin D is a steroid hormone crucial for bone mineral metabolism. In addition, vitamin D has pleiotropic actions in the body, including anti-cancer actions. These anti-cancer properties observed within in vitro studies frequently report the reduction of cell proliferation by interruption of the cell cycle by the direct alteration of cell cycle regulators which induce cell cycle arrest. The most recurrent reported mode of cell cycle arrest by vitamin D is at the G1/G0 phase of the cell cycle. This arrest is mediated by p21 and p27 upregulation, which results in suppression of cyclin D and E activity which leads to G1/G0 arrest. In addition, vitamin D treatments within in vitro cell lines have observed a reduced C-MYC expression and increased retinoblastoma protein levels that also result in G1/G0 arrest. In contrast, G2/M arrest is reported rarely within in vitro studies, and the mechanisms of this arrest are poorly described. Although the relationship of epigenetics on vitamin D metabolism is acknowledged, studies exploring a direct relationship to cell cycle perturbation is limited. In this review, we examine in vitro evidence of vitamin D and vitamin D metabolites directly influencing cell cycle regulators and inducing cell cycle arrest in cancer cell lines.en_ZA
dc.description.departmentChemical Pathologyen_ZA
dc.description.librarianpm2021en_ZA
dc.description.sponsorshipSouth African Medical Research Council (SAMRC)en_ZA
dc.description.urihttp://www.mdpi.com/journal/ijmsen_ZA
dc.identifier.citationBhoora, S.; Punchoo, R. Policing Cancer: Vitamin D Arrests the Cell Cycle. International Journal of Molecular Sciences 2020, 21, 9296. https://doi.org/10.3390/ijms21239296.en_ZA
dc.identifier.issn1661-6596 (print)
dc.identifier.issn1422-0067 (online)
dc.identifier.other10.3390/ijms21239296
dc.identifier.urihttp://hdl.handle.net/2263/79916
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights© 2020 by the authors. Licensee: MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_ZA
dc.subjectCell proliferationen_ZA
dc.subjectCell cycleen_ZA
dc.subjectCyclin-dependent kinaseen_ZA
dc.subjectCyclin-dependent kinase inhibitoren_ZA
dc.subjectVitamin Den_ZA
dc.subjectCalcitriolen_ZA
dc.subjectAnti-proliferationen_ZA
dc.subjectCanceren_ZA
dc.subject.otherHealth sciences articles SDG-03
dc.subject.otherSDG-03: Good health and well-being
dc.titlePolicing cancer : vitamin D arrests the cell cycleen_ZA
dc.typeArticleen_ZA

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