Nuclear organization of cholinergic, putative catecholaminergic, serotonergic and orexinergic systems in the brain of the African pygmy mouse (Mus minutoides) : organizational complexity is preserved in small brains

dc.contributor.authorKruger, Jean-Leigh
dc.contributor.authorPatzke, Nina
dc.contributor.authorFuxe, Kjell
dc.contributor.authorBennett, Nigel Charles
dc.contributor.authorManger, Paul R.
dc.date.accessioned2012-06-06T09:39:38Z
dc.date.available2012-06-06T09:39:38Z
dc.date.issued2012-05
dc.description.abstractThis study investigated the nuclear organization of four immunohistochemically identifiable neural systems (cholinergic, catecholaminergic, serotonergic and orexinergic) within the brain of the African pygmy mouse (Mus minutoides). The African pygmy mice studied had a brain mass of around 275 mg, making these the smallest rodent brains to date in which these neural systems have been investigated. In contrast to the assumption that in this small brain there would be fewer subdivisions of these neural systems, we found that all nuclei generally observed for these systems in other rodent brains were also present in the brain of the African pygmy mouse. As with other rodents previously studied in the subfamily Murinae, we observed the presence of cortical cholinergic neurons and a compactly organized locus coeruleus. These two features of these systems have not been observed in the non-Murinae rodents studied to date. Thus, the African pygmy mouse displays what might be considered a typical Murinae brain organization, and despite its small size, the brain does not appear to be any less complexly organized than other rodent brains, even those that are over 100 times larger such as the Cape porcupine brain. The results are consistent with the notion that changes in brain size do not affect the evolution of nuclear organization of complex neural systems. Thus, species belonging to the same order generally have the same number and complement of the subdivisions, or nuclei, of specific neural systems despite differences in brain size, phenotype or time since evolutionary divergence.en
dc.description.librarianab2012en
dc.description.sponsorshipThe South African National Research Foundation (PRM, NCB), SIDA (KF) and by a fellowship within the Postdoc-Programme of the German Academic Exchange Service, DAAD (NP).en
dc.description.urihttp://www.elsevier.com /locate/jchemneuen
dc.identifier.citationJean-Leigh Kruger, Nina Patzke, Kjell Fuxe, Nigel C. Bennett & Paul R. Manger, Nuclear organization of cholinergic, putative catecholaminergic, serotonergic and orexinergic systems in the brain of the African pygmy mouse (Mus minutoides) : organizational complexity is preserved in small brains, Journal of Chemical Neuroanantomy, vol. 44, no. 1, pp. 45-56 (2012), doi: 10.1016/j.jchemneu.2012.04.002en
dc.identifier.issn0891-0618 (print)
dc.identifier.issn1873-6300 (online)
dc.identifier.other10.1016/j.jchemneu.2012.04.002
dc.identifier.urihttp://hdl.handle.net/2263/19108
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2012 Elsevier B.V. All rights reserved.en
dc.subjectCholine acetyl transferaseen
dc.subjectTyrosline hydroxylaseen
dc.subjectSerotoninen
dc.subjectHypocretinen
dc.subjectEvolutionen
dc.subjectMammalsen
dc.subjectRodentsen
dc.subjectAfrican pygmy mouseen
dc.subjectMus minutoidesen
dc.subject.lcshMiceen
dc.subject.lcshBrainen
dc.titleNuclear organization of cholinergic, putative catecholaminergic, serotonergic and orexinergic systems in the brain of the African pygmy mouse (Mus minutoides) : organizational complexity is preserved in small brainsen
dc.typePostprint Articleen

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