Characterization of Salmonella enterica serovar Isangi from South Africa, 2020–2021

dc.contributor.authorMyataza, Asive
dc.contributor.authorThomas, Juno
dc.contributor.authorSmith, Anthony Marius
dc.date.accessioned2024-03-18T04:27:47Z
dc.date.available2024-03-18T04:27:47Z
dc.date.issued2023-11
dc.descriptionAVAILABILITY OF DATA AND MATERIALS : All sequencing data were uploaded to the public EnteroBase platform (http:// enter obase. warwi ck. ac. uk/ speci es/ index/ sente rica) and so are freely available to access at the EnteroBase platform. In addition, sequencing data are deposited in the European Nucleotide Archive under the project accession numbers PRJEB39546 and PRJEB39988.en_US
dc.descriptionSUPPLEMENTARY INFORMATION : Map of South Africa, showing the different provinces of the country. Provinces (regions) are indicated in different colors.en_US
dc.description.abstractBACKGROUND : We describe the genotypic characteristics and antimicrobial resistance (AMR) determinants of Salmonella enterica serovar Isangi (Salmonella Isangi) clinical isolates in South Africa from 2020 through 2021. METHODS : During the years 2020 to 2021, the Centre for Enteric Diseases of the National Institute for Communicable Diseases, a national reference centre in South Africa for human infections resulting from enteric bacterial pathogens, investigated a total of 3549 clinical isolates of Salmonella species. Whole genome sequencing (WGS) was performed using Illumina NextSeq Technology. WGS data was analyzed using Centre for Genomic Epidemiology-based tools and EnteroBase web-based platform. Genotypic relatedness and cluster analysis was investigated based on coregenome multilocus sequence typing. RESULTS : Forty-nine isolates were confirmed to be Salmonella Isangi, with most submitted from Gauteng Province (24/49, 49%). The most prevalent sequence type was ST335 (48/49, 98%), and the remaining 1 isolate was ST216. All ST335 isolates were genotypically multidrug-resistant (MDR), with resistance to fluoroquinolones, chloramphenicol, trimethoprim-sulfamethoxazole and tetracycline; the ST216 isolate was resistant only to aminoglycosides. All ST335 isolates carried ESBL genes, the most common being blaCTX-M-15. Five clusters (consisting of isolates related within five allele differences) were detected, all being ST335. CONCLUSIONS : Most Salmonella Isangi isolates in South Africa are MDR and ESBL-positive. Ongoing monitoring of the epidemiology and AMR profile of this serovar is important for public health and treatment guidelines.en_US
dc.description.departmentMedical Microbiologyen_US
dc.description.librarianam2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipThe SEQAFRICA project which is funded by the Department of Health and Social Care’s Fleming Fund using UK aid.en_US
dc.description.urihttps://bmcinfectdis.biomedcentral.comen_US
dc.identifier.citationMyataza, A., Thomas, J., Smith, A.M. 2023, 'Characterization of salmonella enterica serovar Isangi from South Africa, 2020–2021', BMC Infectious Diseases, vol. 23, art. 791, pp. 1-6. https://DOI.org/10.1186/s12879-023-08786-9.en_US
dc.identifier.issn1471-2334 (online)
dc.identifier.other10.1186/s12879-023-08786-9
dc.identifier.urihttp://hdl.handle.net/2263/95244
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rights© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.subjectAfricaen_US
dc.subjectSouth Africa (SA)en_US
dc.subjectAntimicrobial resistance (AMR)en_US
dc.subjectSalmonella enterica serovar Isangi (Salmonella Isangi)en_US
dc.subjectWhole genome sequencing (WGS)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.subjectExtended-spectrum β-lactamase (ESBL)en_US
dc.titleCharacterization of Salmonella enterica serovar Isangi from South Africa, 2020–2021en_US
dc.typeArticleen_US

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