Antibacterial and antioxidant activities of the extract and some flavonoids from aerial parts of Echinops Gracilis O. Hoffm. (Asteraceae)
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Date
Authors
Lah, Fidele Castro Weyepe
Missi, Marius Balemaken
October, Natasha
Didoue, Patrick Herve Betote
Ikome, Nalova Hermia Nalova
Abdou, Jean Pierre
Kowa, Theodora Kopa
Agbor, Gabriel
Tchinda, Alembert Tiabou
Dongo, Etienne
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Publisher
Sage
Abstract
Mortality due to microbial diseases continues to be a major problem in many developing countries. The present study aims to evaluate the antibacterial and antioxidant activities of the ethyl acetate extract and some isolated compounds from aerial parts of Echinops gracilis. The phytochemical study resulted in the isolation of a new flavonoid derivative named apigenin-7-O-(4″-feruloyl)-β-D-glucoside (1), together with 2 known compounds: apigenin-7-O-(4″-trans-p-hydroxycinnamoyl)-β-D-glucoside (2), and apigenin-7-O-glucoside (3). Their chemical structures were determined using a combination of NMR and IR spectroscopic and MS techniques, as well as by comparison with literature data. The extract and isolates were evaluated for their antibacterial and antioxydant properties. The EtOAc extract and compounds 1 and 2 showed the ability to scavenge 2,2′-zino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS) with scavenging concentration (SC50) values of 13.6 ± 0.8 µg/mL, 108.2 ± 4.3 µg/mL, and 28.5 ± 2.2 µg/mL, respectively. In addition, compound 1 displayed significant activity against Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia, with minimum inhibition concentration (MIC) values of 31.2, 15.6, and 31.2 µg/mL respectively.
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Keywords
Echinops gracilis, Asteraceae, Flavonoids, Apigenin-7-O-(4"-feruloyl)-β-D-glucoside, Antioxidant, Antibacterial activity
Sustainable Development Goals
Citation
Weyepe Lah, F.C., Balemaken Missi, M., October, N., et al. Antibacterial and Antioxidant Activities of the Extract and Some Flavonoids From Aerial Parts of Echinops Gracilis O. Hoffm. (Asteraceae). Natural Product Communications. 2021;16(3). doi: 10.1177/1934578X21999151.