Krimpsiekte, associated with thalamic lesions, induced by the neurotoxic cardiac glycoside, cotyledoside, isolated from Tylecodon wallichii (Harv.) Toelken subsp. wallichii

dc.contributor.authorBotha, C.J. (Christoffel Jacobus)
dc.contributor.authorVan der Lugt, Jaco J.
dc.contributor.authorErasmus, G.L.
dc.contributor.authorKellerman, T. Stephanus
dc.contributor.authorSchultz, R.A. (Rowena Anitra)
dc.contributor.editorVerwoerd, Daniel Wynand
dc.contributor.upauthorVleggaar, Robert
dc.date.accessioned2012-12-12T08:48:38Z
dc.date.available2012-12-12T08:48:38Z
dc.date.created2012
dc.date.issued1997
dc.descriptionThe articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat X Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.en_US
dc.description.abstractThe specific neurotoxic principle of Tylecodon wallichii (Harv.) Toelken subsp. wallichii, the cause of krimpsiekte in small stock, was isolated and identified as the previously described cumulative bufadienolide, cotyledoside. Krimpsiekte was experimentally induced in two sheep by the repeated intravenous administration of cotyledoside at the rate of 0,01-0,015 mg/kg body mass. On day 9, both animals developed clinical signs typical of krimpsiekte, which is characterized by tremors, paresis and recumbency. Both sheep had difficulty in controlling their hindquarters when attempting to lie down. No significant electrocardiograph abnormalities were detected during the experiment which confirms that cotyledoside at low doses does not overtly affect the electrical activity of the heart. No gross lesions were observed in the sheep. The most significant microscopic lesions comprised mild brain oedema and pronounced vacuolation of the white matter of thalamic nuclei. These lesions might explain some of the motor function deficiencies clinically observed in this syndrome. The previously held contention that these neurotoxic cardiac glycosides are indeed the cause of krimpsiekte is, therefore, confirmed.en_US
dc.identifier.citationBotha, CJ, Van der Lugt, JJ, Erasmus, GL, Kellerman, TS, Schultz, RA & Vleggaar, R 1997, 'Krimpsiekte, associated with thalamic lesions, induced by the neurotoxic cardiac glycoside, cotyledoside, isolated from Tylecodon wallichii (Harv.) Toelken subsp. wallichii’. Onderstepoort Journal of Veterinary Research, vol. 64, no. 3, pp. 189-194.en_US
dc.identifier.issn0330-2465
dc.identifier.other7006558662
dc.identifier.otherO-5991-2014
dc.identifier.urihttp://hdl.handle.net/2263/20743
dc.language.isoenen_US
dc.publisherPublished by the Agricultural Research Council, Onderstepoort Veterinary Instituteen_US
dc.rights© ARC-Onderstepoort (original). © University of Pretoria. Dept of Library Services (digital).en_US
dc.subjectVeterinary medicineen_US
dc.subjectCotyledosideen_US
dc.subjectCumulative bufadienolideen_US
dc.subjectKrimpsiekteen_US
dc.subjectNeurotoxic cardiac glycosideen_US
dc.subjectParesisen_US
dc.subjectSheepen_US
dc.subjectThalamic lesionsen_US
dc.subjectTylecodon wallichiien_US
dc.subject.lcshVeterinary medicine -- South Africa
dc.titleKrimpsiekte, associated with thalamic lesions, induced by the neurotoxic cardiac glycoside, cotyledoside, isolated from Tylecodon wallichii (Harv.) Toelken subsp. wallichiien_US
dc.typeArticleen_US

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