Comprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry for screening of organohalogenated compounds in cat hair

dc.contributor.authorBrits, Martin
dc.contributor.authorGorst-Allman, Peter
dc.contributor.authorRohwer, Egmont Richard
dc.contributor.authorDe Vos, Jayne
dc.contributor.authorDe Boer, Jacob
dc.contributor.authorWeiss, Jana M.
dc.date.accessioned2019-01-23T09:32:07Z
dc.date.issued2018-02
dc.description.abstractThe coupling of comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry offers the best separation efficiency combined with accurate mass measurements over a wide mass range. The tremendous power of this screening tool is illustrated by trace qualitative screening analysis of organohalogenated compounds (OHCs) in pet cat hair. Tentative identification was supported by mass spectral database searches and elemental formula prediction from the experimentally determined accurate mass data. This screening approach resulted in the first tentative identification of pentabromoethylbenzene, decabromodiphenyl ethane, hexabromocyclododecane, trisbromoneopentyl alcohol, tris(2-chloroethyl) phosphate and tris(2-chloroisopropyl)phosphate in the South African indoor environment. A total of seventy-two OHCs were identified in the samples and include known flame retardants, such as polybrominated diphenyl ethers, and legacy contaminants such as polychlorinated biphenyls and organochlorine, organophosphorous and pyrethroid pesticides. The results obtained from cat hair indicate that these pets are exposed to complex mixtures of OHCs and the detection of these compounds suggests that non-invasive cat hair samples can be used to model indoor exposure with reference to external deposition of OHCs present in the air and dust surrounding people. Toddlers share the same environment as pet cats and therefore also the same health risks.en_ZA
dc.description.departmentChemistryen_ZA
dc.description.embargo2019-02-09
dc.description.librarianhj2019en_ZA
dc.description.sponsorshipIn part by the National Research Foundation of South Africa (VU University Amsterdam − NRF Desmond Tutu doctoral scholarship) (Grant number: 94075) and by the Swedish research council FORMAS (Project MiSSE number: 210-2012-131).en_ZA
dc.description.urihttp://www.elsevier.com/locate/chromaen_ZA
dc.identifier.citationBrits, M., Gorst-Allman, P., Rohwer, E.R. et al. 2018, 'Comprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry for screening of organohalogenated compounds in cat hair', Journal of Chromatography A, vol. 1536, pp. 151-162.en_ZA
dc.identifier.issn0021-9673 (print)
dc.identifier.issn1873-3778 (online)
dc.identifier.other10.1016/j.chroma.2017.08.055
dc.identifier.urihttp://hdl.handle.net/2263/68215
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2017 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Chromatography A. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Journal of Chromatography A, vol. 1536, pp. 151-162, 2018. doi : 10.1016/j.chroma.2017.08.055.en_ZA
dc.subjectHigh-resolution time-of-flight mass spectrometryen_ZA
dc.subjectIndoor exposure to pollutantsen_ZA
dc.subjectOrganohalogenated compound (OHC)en_ZA
dc.subjectPet cat hairen_ZA
dc.subjectTwo-dimensional gas chromatographyen_ZA
dc.subjectTris(2-chloroethyl) phosphateen_ZA
dc.subjectPolybrominated diphenyl ether (PBDE)en_ZA
dc.subjectAccurate mass measurementsen_ZA
dc.subjectSpectrometryen_ZA
dc.subjectSmoke detectorsen_ZA
dc.subjectPlasticizersen_ZA
dc.subjectOrganic pollutantsen_ZA
dc.subjectMass spectrometryen_ZA
dc.subjectHealth risksen_ZA
dc.subjectFlame retardant (FR)en_ZA
dc.subjectChromatographyen_ZA
dc.titleComprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry for screening of organohalogenated compounds in cat hairen_ZA
dc.typePostprint Articleen_ZA

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