Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activities

dc.contributor.authorLiang, Yue
dc.contributor.authorZhang, Qi
dc.contributor.authorYang, Xueyuan
dc.contributor.authorLi, Ying
dc.contributor.authorZhang, Xuke
dc.contributor.authorLi, Yuhao
dc.contributor.authorDu, Qing
dc.contributor.authorJin, Da-Qing
dc.contributor.authorCui, Jianlin
dc.contributor.authorLall, Namrita
dc.contributor.authorTuerhong, Muhetaer
dc.contributor.authorLee, Dongho
dc.contributor.authorAbudukeremu, Munira
dc.contributor.authorXu, Jing
dc.contributor.authorShuai, Ling
dc.contributor.authorGuo, Yuanqiang
dc.date.accessioned2021-11-25T10:21:58Z
dc.date.available2021-11-25T10:21:58Z
dc.date.issued2020-05
dc.description.abstractA phytochemical investigation to obtain bioactive substances as lead compounds or agents for cancer led to the obtainment of six new and two known clerodane diterpenoids from the leaves of Casearia kurzii. Their structures were elucidated using NMR techniques and electronic circular dichroism (ECD) calculations. The subsequent biological cytotoxicity evaluation of these isolates toward human lung cancer A549, human cervical cancer HeLa, human chronic myeloid leukemia K562, and human hepatocellular carcinoma HepG2 was carried out. The most active compound 4 with an IC50 value of 9.7 μM against HepG2 cells was selected to examine the cytotoxic mechanism, which induced the apoptosis and arrested the HepG2 cell cycle at S stage. The in vivo zebrafish experiments revealed that compound 4 had the property of inhibiting tumor proliferation and migration.en_ZA
dc.description.departmentPlant Production and Soil Scienceen_ZA
dc.description.librarianhj2021en_ZA
dc.description.sponsorshipThe National Key Research and Development Program of China, the National Natural Science Foundation of China, Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region.en_ZA
dc.description.urihttp://www.elsevier.com/ locate/bmclen_ZA
dc.identifier.citationLiang, Y., Zhang, Q., Yang, X. et al. 2020, 'Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activities', Bioorganic Chemistry, vol. 98, art. 103741, pp. 1-10.en_ZA
dc.identifier.issn0045-2068
dc.identifier.other10.1016/j.bioorg.2020.103741
dc.identifier.urihttp://hdl.handle.net/2263/82848
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2020 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Bioorganic Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Bioorganic Chemistry, vol. 98, art. 103741, pp. 1-10, 2020. doi : 10.1016/j.bioorg.2020.103741.en_ZA
dc.subjectZebrafish xenograft modelen_ZA
dc.subjectCytotoxic activitiesen_ZA
dc.subjectApoptosisen_ZA
dc.subjectCell cycleen_ZA
dc.subjectClerodane diterpenoidsen_ZA
dc.subjectCasearia kurziien_ZA
dc.subjectElectronic circular dichroism (ECD)en_ZA
dc.titleDiterpenoids from the leaves of Casearia kurzii showing cytotoxic activitiesen_ZA
dc.typePostprint Articleen_ZA

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